Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 13/20 | 0.36 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7563771 | 0.89 | ACHE (0.44) | ACHEMAOBPARK7HTR2C | |
| SCHEMBL28108222 | 0.81 | ACHE (0.39) | ACHEMAOBHTR2C | |
| SCHEMBL2418665 | 0.79 | FFAR1 (0.44) | ACHEMAOB | |
| SCHEMBL7566360 | 0.76 | TRPA1 (0.36) | ACHE | |
| SCHEMBL7566366 | 0.76 | TRPA1 (0.36) | ACHE | |
| SCHEMBL7566372 | 0.76 | TRPA1 (0.36) | ACHE | |
| SCHEMBL8143490 | 0.76 | MAOA (0.39) | ACHEMAOB | |
| SCHEMBL8143488 | 0.76 | MAOA (0.39) | ACHEMAOB | |
| SCHEMBL7565845 | 0.76 | FFAR4 (0.34) | ACHE | |
| SCHEMBL7565855 | 0.76 | FFAR4 (0.34) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0987248-B1 | Amide derivatives and their therapeutic use | WELLCOME FOUND (GB) | 2002-09-04 | — | — | EP | disclosed |
| EP-0699180-B1 | BICYCLIC AMIDE DERIVATIVES AND THEIR USE AS MUSCLE RELAXANTS | WELLCOME FOUND (GB) | 2000-11-22 | — | — | EP | disclosed |
| US-6124284-A | REDUCED SIDE EFFECTS | GLAXO WELLCOME INC. (US) | 2000-09-26 | — | — | US | disclosed |
| EP-0987248-A1 | Amide derivatives and their therapeutic use | THE WELLCOME FOUNDATION LIMITED (GB) | 2000-03-22 | — | — | EP | disclosed |
| US-5872118-A | RELAXATION OF SKELETAL MUSCLE IN SPASTIC, HYPERTONIC AND HYPERKINETIC CONDITIONS | GLAXO WELLCOME INC. (US) | 1999-02-16 | — | — | US | disclosed |
| WO-1994026692-A1 | BICYCLIC AMIDE DERIVATIVES AND THEIR USE AS MUSCLE RELAXANTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-11-24 | — | — | WO | disclosed |