Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 13/20 | 0.58 |
| ▸ | PNP | P00491 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9765190 | 0.82 | HPRT1 (0.59) | HPRT1PNPMEN1LMNAKMT2A | |
| SCHEMBL6428435 | 0.81 | ADORA2B (0.52) | HPRT1PNP | |
| SCHEMBL24239249 | 0.79 | HPRT1 (0.63) | HPRT1PNPMEN1LMNAKMT2A | |
| SCHEMBL9192714 | 0.79 | HPRT1 (0.51) | HPRT1PNPMEN1LMNAKMT2A | |
| SCHEMBL1993930 | 0.79 | HPRT1 (0.63) | HPRT1PNPMEN1LMNAKMT2A | |
| SCHEMBL455645 | 0.78 | HPRT1 (0.62) | HPRT1PNPMEN1LMNAKMT2A | |
| SCHEMBL669006 | 0.78 | TK1 (0.68) | HPRT1PNPMEN1LMNAKMT2A | |
| SCHEMBL11258920 | 0.76 | HPRT1 (0.69) | HPRT1PNP | |
| SCHEMBL20782416 | 0.76 | HPRT1 (0.65) | HPRT1PNP | |
| SCHEMBL22381490 | 0.75 | HPRT1 (0.63) | HPRT1PNPMEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5734053-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE AGENTS | PFIZER INC (US) | 1998-03-31 | — | — | US | disclosed |
| EP-0647227-B1 | PURINONE ANTIANGINAL AGENTS | PFIZER LTD (GB) | 1996-10-09 | — | — | EP | disclosed |
| EP-0647227-A1 | PURINONE ANTIANGINAL AGENTS. | PFIZER LTD (GB) | 1995-04-12 | — | — | EP | disclosed |
| WO-1994000453-A1 | PURINONE ANTIANGINAL AGENTS | PFIZER LIMITED (GB) | 1994-01-06 | — | — | WO | disclosed |