Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | GBA1 | P04062 | 1/20 | 0.58 |
| ▸ | P2RX7 | Q99572 | 9/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7573037 | 0.82 | P2RX7 (0.69) | P2RX7MEN1KMT2AALDH1A1 | |
| SCHEMBL7572585 | 0.80 | P2RX7 (0.70) | HPGDP2RX7MEN1KMT2AALDH1A1 | |
| SCHEMBL8381564 | 0.74 | P2RX7 (0.72) | P2RX7 | |
| SCHEMBL7572613 | 0.74 | P2RX7 (0.72) | HPGDP2RX7MEN1MAPTHTT | |
| SCHEMBL7570510 | 0.73 | P2RX7 (0.60) | P2RX7LMNAMEN1MAPTKMT2A | |
| SCHEMBL7568670 | 0.73 | P2RX7 (0.71) | P2RX7MEN1KMT2AALDH1A1 | |
| SCHEMBL31424200 | 0.73 | P2RX7 (0.76) | P2RX7 | |
| SCHEMBL14160432 | 0.73 | P2RX7 (0.71) | P2RX7 | |
| SCHEMBL7570190 | 0.73 | P2RX7 (1.00) | P2RX7LMNA | |
| SCHEMBL7568709 | 0.73 | P2RX7 (1.00) | P2RX7MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036059-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2002-09-18 | — | — | EP | claimed |
| EP-1036059-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2002-09-18 | — | — | EP | disclosed |