Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 5/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL407661 | 0.71 | DGAT1 (0.47) | MAPTLMNAMAPK1HTTALDH1A1 | |
| SCHEMBL2045755 | 0.69 | MTOR (0.44) | MAPTTSHRDRD2ALDH1A1HTR1A | |
| SCHEMBL1528319 | 0.69 | MAPT (0.52) | MAPTNPC1RAB9ADRD2ALDH1A1 | |
| SCHEMBL31149031 | 0.69 | MTOR (0.44) | MAPTTSHRDRD2ALDH1A1HTR1A | |
| SCHEMBL6173838 | 0.69 | GRIA2 (0.40) | MAPTLMNAHTTNPC1ALDH1A1 | |
| SCHEMBL5801912 | 0.68 | MTOR (0.43) | ARMAPTLMNANPC1KCNN4 | |
| SCHEMBL29524027 | 0.68 | TSHR (0.41) | ARMAPTLMNATSHRHTT | |
| SCHEMBL1195395 | 0.67 | LMNA (0.37) | ARMAPTLMNAHTTALDH1A1 | |
| SCHEMBL6170354 | 0.66 | MEN1 (0.43) | MAPTLMNAHTTNPC1RAB9A | |
| SCHEMBL7241605 | 0.65 | MEN1 (0.45) | MAPTTSHRMAPK1HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0991625-A2 | INHIBITORS OF FACTOR XA WITH A NEUTRAL P1 SPECIFICITY GROUP | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 2000-04-12 | — | — | EP | disclosed |
| WO-1998057937-A2 | INHIBITORS OF FACTOR XA WITH A NEUTRAL P1 SPECIFICITY GROUP | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-12-23 | — | — | WO | disclosed |