Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | PTGES2 | Q9H7Z7 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.56 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.55 |
| ▸ | CLK1 | P49759 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | MMP1 | P03956 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
| ▸ | MMP9 | P14780 | 1/20 | 0.52 |
| ▸ | MMP8 | P22894 | 1/20 | 0.52 |
| ▸ | MMP13 | P45452 | 1/20 | 0.52 |
| ▸ | ACLY | P53396 | 1/20 | 0.52 |
| ▸ | IDH1 | O75874 | 2/20 | 0.52 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7592771 | 0.88 | MEN1 (0.74) | MEN1KMT2AGAAPTGES2LMNA | |
| SCHEMBL7580383 | 0.85 | MCL1 (0.68) | MCL1MEN1KMT2AGAAPTGES2 | |
| SCHEMBL10585396 | 0.84 | PTGES2 (0.66) | MEN1KMT2AGAAPTGES2LMNA | |
| SCHEMBL10143421 | 0.84 | MEN1 (0.66) | MEN1KMT2AGAAPTGES2LMNA | |
| SCHEMBL7572596 | 0.82 | MEN1 (0.67) | MEN1KMT2AGAAPTGES2LMNA | |
| SCHEMBL10582379 | 0.82 | MEN1 (0.64) | MEN1KMT2AGAAPTGES2LMNA | |
| SCHEMBL120756 | 0.81 | CYP1A2 (0.67) | MCL1IDH1 | |
| SCHEMBL7573750 | 0.81 | ACLY (0.56) | MEN1KMT2AGAAPTGES2LMNA | |
| SCHEMBL13852835 | 0.81 | HSD17B2 (0.57) | MCL1MEN1KMT2AGAAPTGES2 | |
| SCHEMBL10530997 | 0.79 | ALDH1A1 (0.64) | MEN1KMT2AGAAPTGES2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |