Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HBB | P68871 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9185844 | 0.75 | — | — | |
| SCHEMBL9190332 | 0.75 | — | — | |
| SCHEMBL4566315 | 0.75 | TSHR (0.39) | MEN1KMT2ALMNATSHR | |
| SCHEMBL9190953 | 0.72 | CNR2 (0.48) | MEN1KMT2AMAPTLMNA | |
| SCHEMBL6690514 | 0.72 | EGFR (0.30) | — | |
| SCHEMBL2485392 | 0.72 | EGFR (0.30) | — | |
| SCHEMBL995245 | 0.70 | MEN1 (0.39) | MEN1KMT2AMAPTLMNATP53 | |
| SCHEMBL4556547 | 0.70 | — | — | |
| SCHEMBL9190309 | 0.70 | USP2 (0.46) | LMNATSHR | |
| SCHEMBL9000091 | 0.69 | EGFR (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841912-B1 | ANTITUMOR 2-AMINOCARBONYL-1,2-BIS(METHYLSULFONYL)-1-(SUBSTITUTED)HYDRAZINES | UNIV YALE (US) | 2002-09-25 | — | — | EP | disclosed |
| EP-0841912-A4 | ANTITUMOR 2-AMINOCARBONYL-1,2-BIS(METHYLSULFONYL)-1-(SUBSTITUTED)HYDRAZINES | UNIV YALE (US) | 1998-10-14 | — | — | EP | disclosed |
| EP-0841912-A1 | ANTITUMOR 2-AMINOCARBONYL-1,2-BIS(METHYLSULFONYL)-1-(SUBSTITUTED)HYDRAZINES | YALE UNIVERSITY (US) | 1998-05-20 | — | — | EP | disclosed |
| US-5637619-A | Antitumor 2-aminocarbonyl-1, 2-bis(methylsulfonyl)-1-(substituted)hydrazines | YALE UNIVERSITY (US) | 1997-06-10 | — | — | US | disclosed |
| WO-1997002029-A1 | ANTITUMOR 2-AMINOCARBONYL-1,2-BIS(METHYLSULFONYL)-1-(SUBSTITUTED)HYDRAZINES | YALE UNIVERSITY (US) | 1997-01-23 | — | — | WO | disclosed |
| EP-0541322-B1 | 1-Alkyl-2-acyl-1,2-disulfonylhydrazines with antineoplastic activity | UNIV YALE (US) | 1996-09-11 | — | — | EP | disclosed |
| EP-0416286-B1 | Sulfonylhydrazines and their use as antineoplastic agents and as antitrypanosomal agents | UNIV YALE (US) | 1995-08-09 | — | — | EP | disclosed |
| US-5256820-A | Anticarcinogenic agents | YALE UNIVERSITY (US) | 1993-10-26 | — | — | US | disclosed |
| US-5214068-A | Anticarcinogenic agents | YALE UNIVERSITY (US) | 1993-05-25 | — | — | US | disclosed |
| EP-0541322-A1 | 1-Alkyl-2-acyl-1,2-disulfonylhydrazines with antineoplastic activity | YALE UNIVERSITY (US) | 1993-05-12 | — | — | EP | disclosed |
| US-5101072-A | Anticancer agents, trypanocides | YALE UNIVERSITY (US) | 1992-03-31 | — | — | US | disclosed |
| EP-0416286-A1 | Sulfonylhydrazines and their use as antineoplastic agents and as antitrypanosomal agents | YALE UNIVERSITY (US) | 1991-03-13 | — | — | EP | disclosed |