⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31367857 | 0.84 | ALOX5 (0.39) | — | |
| SCHEMBL16345466 | 0.78 | — | — | |
| SCHEMBL9906388 | 0.78 | — | — | |
| SCHEMBL16345143 | 0.78 | — | — | |
| SCHEMBL1799185 | 0.78 | ALOX5 (0.43) | — | |
| SCHEMBL6643512 | 0.75 | ALOX5 (0.37) | — | |
| SCHEMBL13626441 | 0.75 | ALOX5 (0.37) | — | |
| SCHEMBL11272511 | 0.75 | RAB9A (0.40) | — | |
| SCHEMBL6240281 | 0.75 | ALOX5 (0.48) | — | |
| SCHEMBL5517928 | 0.74 | ALOX5 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240425517-A1 | NOVEL COMPOUND FOR DEGRADATION OF TARGET PROTEIN OR POLYPEPTIDE BY POLYUBIQUITINATION | PRAZER THERAPEUTICS INC. (KR) | 2024-12-26 | — | — | US | claimed |
| US-20240425517-A1 | NOVEL COMPOUND FOR DEGRADATION OF TARGET PROTEIN OR POLYPEPTIDE BY POLYUBIQUITINATION | PRAZER THERAPEUTICS INC. (KR) | 2024-12-26 | — | — | US | disclosed |
| CN-118382620-A | Novel compounds for degrading target proteins or polypeptides by multiple ubiquitination | 普瑞泽治疗公司 | 2024-07-23 | — | — | CN | disclosed |
| EP-0810199-B1 | Method for producing propargylamine compounds | SUMITOMO CHEMICAL CO (JP) | 2002-09-25 | — | — | EP | disclosed |
| US-5756769-A | Method for producing propargylamine compounds | SUMITOMO CHEMICAL COMPANY, LTD. (JP) | 1998-05-26 | — | — | US | disclosed |
| EP-0810199-A1 | Method for producing propargylamine compounds | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1997-12-03 | — | — | EP | disclosed |
| EP-0281018-A1 | Heterocyclyl-2-propyn-1-amines | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-09-07 | — | — | EP | disclosed |
| US-4743617-A | HYPOTENSIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-05-10 | — | — | US | disclosed |