Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 8/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7571707 | 0.85 | P2RX7 (0.57) | P2RX7MEN1KMT2AHPGDRAB9A | |
| SCHEMBL7571525 | 0.84 | P2RX7 (0.55) | P2RX7MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL3458610 | 0.84 | P2RX7 (0.68) | P2RX7MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7571682 | 0.82 | ALDH1A1 (0.60) | P2RX7MEN1KMT2AALDH1A1 | |
| SCHEMBL7571520 | 0.82 | P2RX7 (0.58) | P2RX7MEN1KMT2AALDH1A1 | |
| SCHEMBL7572019 | 0.82 | P2RX7 (0.62) | P2RX7MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL13958643 | 0.81 | P2RX7 (0.58) | P2RX7MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7572974 | 0.81 | P2RX7 (0.60) | P2RX7MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7570015 | 0.81 | P2RX7 (0.54) | P2RX7MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7578023 | 0.81 | P2RX7 (0.49) | P2RX7MEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036059-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2002-09-18 | — | — | EP | claimed |
| EP-1036059-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2002-09-18 | — | — | EP | disclosed |