Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 8/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7571682 | 0.89 | ALDH1A1 (0.60) | P2RX7ALDH1A1SMN1; SMN2POLBATM | |
| SCHEMBL7572059 | 0.85 | P2RX7 (0.60) | P2RX7ALDH1A1KMT2AHPGDMEN1 | |
| SCHEMBL7572957 | 0.84 | RAB9A (0.48) | P2RX7ALDH1A1GAASMN1; SMN2ATM | |
| SCHEMBL7571586 | 0.83 | P2RX7 (0.46) | P2RX7ALDH1A1SMN1; SMN2POLBATM | |
| SCHEMBL3458610 | 0.81 | P2RX7 (0.68) | P2RX7ALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL7570015 | 0.80 | P2RX7 (0.54) | P2RX7ALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL7571525 | 0.79 | P2RX7 (0.55) | P2RX7ALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL1514728 | 0.78 | ALDH1A1 (0.66) | ALDH1A1GAASMN1; SMN2POLBATM | |
| SCHEMBL7569262 | 0.77 | P2RX7 (0.57) | P2RX7ALDH1A1SMN1; SMN2POLBKMT2A | |
| SCHEMBL7572019 | 0.77 | P2RX7 (0.62) | P2RX7ALDH1A1KMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036059-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2002-09-18 | — | — | EP | claimed |
| EP-1036059-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2002-09-18 | — | — | EP | disclosed |