Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 9/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.55 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.52 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | CDC7 | O00311 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11934937 | 0.88 | ROCK2 (0.51) | ROCK2ROCK1PKN2TRPM5RAB9A | |
| SCHEMBL10936657 | 0.87 | INSR (0.55) | RAB9AKDM4EMEN1ALDH1A1GAA | |
| SCHEMBL13122158 | 0.80 | ROCK2 (0.55) | ROCK2ROCK1TRPM5RAB9AMKNK1 | |
| SCHEMBL12257075 | 0.80 | JAK2 (0.60) | ROCK2ROCK1TRPM5RAB9AMKNK1 | |
| SCHEMBL13122090 | 0.78 | ROCK2 (0.68) | ROCK2ROCK1TRPM5RAB9ANPC1 | |
| SCHEMBL5564049 | 0.78 | MKNK1 (0.60) | ROCK2ROCK1RAB9AMKNK1KDM4E | |
| SCHEMBL13030190 | 0.77 | ROCK2 (0.58) | ROCK2ROCK1TRPM5RAB9ANPC1 | |
| SCHEMBL13122244 | 0.76 | ROCK2 (0.54) | ROCK2ROCK1TRPM5RAB9AMKNK1 | |
| Hydrochloric Acid SCHEMBL2082481 | 0.76 | MKNK1 (0.59) | ROCK2ROCK1RAB9AMKNK1KDM4E | |
| SCHEMBL13122377 | 0.76 | TRPM5 (0.53) | ROCK2ROCK1TRPM5RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0904769-B1 | Keratin fibre dye compositions containing Indazole amine derivatives and dyeing method | OREAL (FR) | 2002-09-25 | — | — | EP | claimed |
| EP-0904769-A1 | Keratin fibre dye compositions containing Indazole amine derivatives and dyeing method | L'OREAL (FR) | 1999-03-31 | — | — | EP | claimed |
| EP-0904769-B1 | Keratin fibre dye compositions containing Indazole amine derivatives and dyeing method | OREAL (FR) | 2002-09-25 | — | — | EP | disclosed |
| US-6027538-A | OXIDATION DYEING OF KERATINOUS FIBERS CONTAINING AT LEAST ONE COUPLER SELECTED FROM INDAZOLEAMINE DERIVATIVES AND AT LEAST ONE OXIDATION BASE; POWERFUL, NOT VERY SELECTIVE HAIR DYES WHICH ARE CAPABLE OF GENERATING INTENSE COLOR | L'OREAL S.A. (FR) | 2000-02-22 | — | — | US | disclosed |
| EP-0904769-A1 | Keratin fibre dye compositions containing Indazole amine derivatives and dyeing method | L'OREAL (FR) | 1999-03-31 | — | — | EP | disclosed |
| US-4608383-A | Cardioactive pyrazole and imidazole aryloxypropanolamines | BOEHRINGER MANNHEIM GMBH (DE) | 1986-08-26 | — | — | US | disclosed |
| EP-0042593-B1 | ARYLOXY-PROPANOL AMINES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THESE COMPOUNDS | Roche Diagnostics GmbH (DE) | 1985-04-03 | — | — | EP | disclosed |
| US-4507488-A | N-Pyrazolylalkylenediamine intermediates | BOEHRINGER MANNHEIM GMBH (DE) | 1985-03-26 | — | — | US | disclosed |
| EP-0042592-B1 | N-HETEROARYLALKYLENE DIAMINES, PROCESS FOR THEIR PREPARATION AND THEIR USE | Roche Diagnostics GmbH (DE) | 1985-01-30 | — | — | EP | disclosed |
| US-4438128-A | ADRENERGIC BLOCKERS | BOEHRINGER MANNHEIM GMBH (DE) | 1984-03-20 | — | — | US | disclosed |
| EP-0042593-A1 | Aryloxy-propanol amines, process for their preparation and medicines containing these compounds | Roche Diagnostics GmbH (DE) | 1981-12-30 | — | — | EP | disclosed |
| EP-0042592-A1 | N-heteroarylalkylene diamines, process for their preparation and their use | Roche Diagnostics GmbH (DE) | 1981-12-30 | — | — | EP | disclosed |