Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.66 |
| ▸ | SRC | P12931 | 2/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.56 |
| ▸ | RET | P07949 | 3/20 | 0.56 |
| ▸ | KDR | P35968 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7573786 | 0.88 | SRC (0.80) | EGFRSRCERBB2RETKDR | |
| SCHEMBL18158243 | 0.85 | EGFR (0.72) | EGFRSRCRETKDRRIPK2 | |
| SCHEMBL159652 | 0.82 | KDR (0.80) | EGFRSRCERBB2RETKDR | |
| SCHEMBL30891782 | 0.82 | EGFR (0.83) | EGFRSRCERBB2RETKDR | |
| SCHEMBL7572715 | 0.82 | KDR (0.59) | EGFRSRCERBB2KDRFLT1 | |
| SCHEMBL7572708 | 0.82 | KDR (0.59) | EGFRSRCERBB2KDRFLT1 | |
| Hydrochloric Acid SCHEMBL1468204 | 0.81 | KDR (0.78) | EGFRSRCERBB2RETKDR | |
| SCHEMBL242224 | 0.81 | EGFR (0.78) | EGFRERBB2RETKDRRIPK2 | |
| SCHEMBL30141491 | 0.81 | EGFR (0.78) | EGFRERBB2RETKDRRIPK2 | |
| SCHEMBL7575453 | 0.81 | SRC (0.61) | EGFRSRCRETKDRRIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002092577-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2002-11-21 | — | — | WO | disclosed |