Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 1/20 | 0.52 |
| ▸ | TACR1 | P25103 | 15/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | UGCG | Q16739 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12798415 | 0.92 | GHSR (0.53) | GHSRTACR1PPARACTSSCYP3A4 | |
| SCHEMBL8843163 | 0.91 | GHSR (0.47) | GHSRTACR1PPARACTSSCYP3A4 | |
| SCHEMBL5700753 | 0.87 | GHSR (0.55) | GHSRTACR1CYP3A4UGCG | |
| SCHEMBL7572189 | 0.86 | GHSR (0.47) | GHSRTACR1PPARACTSSCYP3A4 | |
| SCHEMBL5700750 | 0.83 | GHSR (0.53) | GHSRTACR1CYP3A4UGCG | |
| SCHEMBL5700749 | 0.83 | GHSR (0.53) | GHSRTACR1CYP3A4UGCG | |
| SCHEMBL8311164 | 0.83 | GHSR (0.53) | GHSRTACR1PPARACTSSCYP3A4 | |
| SCHEMBL8311168 | 0.83 | GHSR (0.53) | GHSRTACR1PPARACTSSCYP3A4 | |
| SCHEMBL7567562 | 0.82 | GHSR (0.59) | GHSRTACR1 | |
| SCHEMBL30661940 | 0.82 | GHSR (0.78) | GHSRTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0615977-B1 | Spiro piperidines and homologs which promote release of growth hormone | MERCK & CO INC (US) | 2002-07-03 | — | — | EP | disclosed |
| US-5652235-A | Method of using spiro piperidines to promote the release of growth hormone | MERCK & CO., INC. (US) | 1997-07-29 | — | — | US | disclosed |
| US-5536716-A | Spiro piperidines and homologs which promote release of growth hormone | MERCK & CO., INC. (US) | 1996-07-16 | — | — | US | disclosed |
| EP-0615977-A1 | Spiro piperidines and homologs which promote release of growth hormone | MERCK & CO. INC. (US) | 1994-09-21 | — | — | EP | disclosed |