Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | KDM1A | O60341 | 2/20 | 0.53 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7578595 | 0.89 | NPSR1 (0.72) | NPSR1LMNAALDH1A1KDM4EMAPT | |
| SCHEMBL7572555 | 0.88 | CYP2C9 (0.60) | NPSR1LMNAALDH1A1KDM4EKDM1A | |
| SCHEMBL7570517 | 0.79 | CYP2C9 (0.61) | NPSR1LMNAALDH1A1KDM4EMAPT | |
| SCHEMBL7572561 | 0.79 | NPSR1 (0.66) | NPSR1LMNAALDH1A1KDM4EMAPT | |
| SCHEMBL28572592 | 0.79 | MAPT (0.65) | NPSR1LMNAALDH1A1KDM4EMAPT | |
| SCHEMBL395600 | 0.78 | HIF1A (0.61) | NPSR1LMNAALDH1A1MAPTHIF1A | |
| SCHEMBL1071830 | 0.78 | CYP2C9 (0.79) | NPSR1LMNAALDH1A1KDM4EMAPT | |
| SCHEMBL7573951 | 0.78 | NPSR1 (0.59) | NPSR1LMNAALDH1A1KDM4EMAPT | |
| SCHEMBL7573948 | 0.78 | NPSR1 (0.59) | NPSR1LMNAALDH1A1KDM4EMAPT | |
| SCHEMBL7567314 | 0.78 | NPSR1 (0.59) | NPSR1LMNAALDH1A1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |