Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | CASP4 | P49662 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | CASP9 | P55211 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PMM2 | O15305 | 1/20 | 0.36 |
| ▸ | MPI | P34949 | 1/20 | 0.36 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL754188 | 0.87 | MAPT (0.46) | NR3C2POLBKMT2AALDH1A1CASP1 | |
| SCHEMBL759695 | 0.86 | NR3C2 (0.45) | NR3C2ARKMT2AALDH1A1CASP1 | |
| SCHEMBL758117 | 0.84 | NR3C2 (0.43) | NR3C2KMT2AALDH1A1CASP1CASP3 | |
| SCHEMBL758387 | 0.83 | NR3C2 (0.53) | NR3C2POLBARCACNA1BAPBA1 | |
| SCHEMBL756076 | 0.83 | NR3C2 (0.43) | NR3C2POLBARKMT2AALDH1A1 | |
| SCHEMBL2264897 | 0.83 | NR3C2 (0.42) | NR3C2POLBKMT2AALDH1A1CASP1 | |
| SCHEMBL756905 | 0.82 | NR3C2 (0.52) | NR3C2POLBARCACNA1BAPBA1 | |
| SCHEMBL16978177 | 0.82 | NR3C2 (0.65) | NR3C2POLBARCACNA1BAPBA1 | |
| SCHEMBL757925 | 0.81 | NR3C2 (0.45) | NR3C2POLBARCACNA1BAPBA1 | |
| SCHEMBL756166 | 0.81 | NR3C2 (0.45) | NR3C2POLBARCACNA1BAPBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9751846-B2 | Method for producing 1,4-benzoxazine compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2017-09-05 | — | — | US | disclosed |
| US-9751846-B2 | Method for producing 1,4-benzoxazine compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2017-09-05 | — | — | US | disclosed |
| EP-3112354-A1 | METHOD FOR PRODUCING 1,4-BENZOXAZINE COMPOUND | Mitsubishi Tanabe Pharma Corporation (JP) | 2017-01-04 | — | — | EP | disclosed |
| US-20160362385-A1 | METHOD FOR PRODUCING 1,4-BENZOXAZINE COMPOUND | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2016-12-15 | — | — | US | disclosed |
| US-20160362385-A1 | METHOD FOR PRODUCING 1,4-BENZOXAZINE COMPOUND | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2016-12-15 | — | — | US | disclosed |
| US-9409874-B2 | Method for producing 1,4-benzoxazine compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2016-08-09 | — | — | US | disclosed |
| US-9409874-B2 | Method for producing 1,4-benzoxazine compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2016-08-09 | — | — | US | disclosed |
| US-20150218113-A1 | METHOD FOR PRODUCING 1,4-BENZOXAZINE COMPOUND | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2015-08-06 | — | — | US | disclosed |
| US-20150218113-A1 | METHOD FOR PRODUCING 1,4-BENZOXAZINE COMPOUND | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2015-08-06 | — | — | US | disclosed |
| EP-2883870-A1 | METHOD FOR PRODUCING 1,4-BENZOXAZINE COMPOUND | Mitsubishi Tanabe Pharma Corporation (JP) | 2015-06-17 | — | — | EP | disclosed |
| US-8188073-B2 | Benzoxazines and related nitrogen-containing heterobicyclic compounds useful as mineralocorticoid receptor modulating agents | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-05-29 | — | — | US | disclosed |
| EP-1984345-B9 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-03-21 | — | — | EP | disclosed |
| US-20110251185-A1 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | IIJIMA TORU | 2011-10-13 | — | — | US | disclosed |
| EP-1984345-B1 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | MITSUBISHI TANABE PHARMA CORP (JP) | 2011-08-31 | — | — | EP | disclosed |
| US-7998956-B2 | Benzoxazines and related nitrogen-containing heterobicyclic compounds useful as mineralocorticoid receptor modulating agents | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-08-16 | — | — | US | disclosed |
| US-20090023716-A1 | Benzoxazines and Related Nitrogen-Containing Heterobicyclic Compounds Useful as Mineralocorticoid Receptor Modulating Agents | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2009-01-22 | — | — | US | disclosed |
| EP-1984345-A1 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | Mitsubishi Tanabe Pharma Corporation (JP) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007089034-A1 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2007-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150218113-A1 | METHOD FOR PRODUCING 1,4-BENZOXAZINE COMPOUND | BRSK1, BRSK2, MSMO1 | NR3C2 1315/4885POLB 4702/4885AR 963/4885 |
| US-20090023716-A1 | Benzoxazines and Related Nitrogen-Containing Heterobicyclic Compounds Useful as Mineralocorticoid Receptor Modulating Agents | NR3C2, MC2R, NR3C1 | NR3C2 1/4885POLB 3875/4885AR 18/4885 |
| US-20160362385-A1 | METHOD FOR PRODUCING 1,4-BENZOXAZINE COMPOUND | BRSK1, BRSK2, MSMO1 | NR3C2 1315/4885POLB 4702/4885AR 963/4885 |
| US-20110251185-A1 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | NR3C2, MC2R, NR3C1 | NR3C2 1/4885POLB 3875/4885AR 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.