Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | RAB9A | P51151 | 4/20 | 0.66 |
| ▸ | NPC1 | O15118 | 3/20 | 0.66 |
| ▸ | CASP3 | P42574 | 1/20 | 0.66 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.59 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.59 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10144733 | 0.92 | KMT2A (0.64) | KMT2APOLBRAB9ANPC1CASP3 | |
| SCHEMBL11819922 | 0.90 | MAPT (0.68) | KMT2APOLBRAB9ANPC1CASP3 | |
| SCHEMBL7302951 | 0.89 | SERPINE1 (0.71) | KMT2APOLBRAB9ANPC1CASP3 | |
| SCHEMBL19462489 | 0.88 | HDAC1 (0.73) | KMT2APOLBRAB9ANPC1CASP3 | |
| SCHEMBL22075849 | 0.86 | POLB (0.69) | KMT2APOLBRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL18585818 | 0.85 | MAPT (0.61) | KMT2APOLBRAB9ANPC1CASP3 | |
| SCHEMBL11314697 | 0.85 | NPC1 (0.61) | KMT2APOLBRAB9ANPC1CASP3 | |
| SCHEMBL11514088 | 0.85 | NOX1 (0.63) | KMT2APOLBRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11309788 | 0.85 | RAB9A (0.61) | KMT2APOLBRAB9ANPC1CASP3 | |
| SCHEMBL21620277 | 0.83 | POLB (0.74) | KMT2APOLBRAB9ANPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476045-B2 | INDOLE AND AZAINDOLE DERIVATIVES AND THEIR USE AS TACHYKININ ANTAGONISTS, AND IN PARTICULAR AS NEUROKININ-1 RECEPTOR ANTAGONIST | MERCK SHARP & DOHME LTD. (GB) | 2002-11-05 | — | — | US | disclosed |
| US-20020022624-A1 | Azaindole derivatives and their use as therapeutic agents | MERCK SHARP & DOHME LTD. (GB) | 2002-02-21 | — | — | US | disclosed |
| US-20010039286-A1 | 2-aryl indole derivatives and their use as therapeutic agents | DINNELL KEVIN (GB) | 2001-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010039286-A1 | 2-aryl indole derivatives and their use as therapeutic agents | IDO1, IDO2, CNR2 | KMT2A 2907/4885POLB 2886/4885RAB9A 3504/4885 |
| US-20020022624-A1 | Azaindole derivatives and their use as therapeutic agents | HTR2B, HNMT, HTR1B | KMT2A 987/4885POLB 2261/4885RAB9A 2962/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.