Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 6/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | GAA | P10253 | 3/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | CYTH2 | Q99418 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | GPR27 | Q9NS67 | 4/20 | 0.55 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.55 |
| ▸ | IL1RN | P18510 | 1/20 | 0.55 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.55 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8976245 | 0.87 | PKM (0.67) | PKMALDH1A1GAAHTTALOX15 | |
| SCHEMBL5163794 | 0.85 | LMNA (0.62) | PKMALDH1A1GAAHTTALOX15 | |
| SCHEMBL30343351 | 0.85 | PKM (0.69) | PKMALDH1A1GAAHTTALOX15 | |
| SCHEMBL7577338 | 0.85 | PKM (0.69) | PKMALDH1A1GAAHTTALOX15 | |
| SCHEMBL23109220 | 0.84 | CDC7 (0.58) | PKMALDH1A1HTTMEN1KMT2A | |
| SCHEMBL4955646 | 0.82 | CYTH2 (0.64) | PKMALDH1A1GAAHTTALOX15 | |
| SCHEMBL3780986 | 0.82 | GAA (0.67) | PKMALDH1A1GAAHTTALOX15 | |
| SCHEMBL14606818 | 0.81 | CYTH2 (0.77) | PKMALDH1A1GAAHTTALOX15 | |
| SCHEMBL3930917 | 0.81 | FFAR4 (0.68) | PKMALDH1A1GAAHTTALOX15 | |
| SCHEMBL16041517 | 0.81 | LMNA (0.57) | PKMALDH1A1GAAHTTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |