Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | WDR5 | P61964 | 4/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | ALPL | P05186 | 2/20 | 0.61 |
| ▸ | MYC | P01106 | 1/20 | 0.58 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7594909 | 0.94 | NPC1 (0.89) | NPC1TSHRWDR5MEN1KMT2A | |
| SCHEMBL7578214 | 0.84 | USP2 (0.73) | NPC1TSHRWDR5MEN1KMT2A | |
| SCHEMBL7589293 | 0.84 | NPC1 (0.72) | NPC1TSHRWDR5MEN1KMT2A | |
| SCHEMBL7578345 | 0.83 | WDR5 (0.73) | NPC1TSHRWDR5MEN1KMT2A | |
| SCHEMBL7587628 | 0.82 | NPC1 (0.70) | NPC1TSHRWDR5MEN1KMT2A | |
| SCHEMBL27908886 | 0.82 | TSHR (0.69) | NPC1TSHRWDR5MEN1KMT2A | |
| SCHEMBL12368225 | 0.81 | ACLY (0.75) | NPC1TSHR | |
| SCHEMBL7586724 | 0.81 | NPC1 (0.68) | NPC1TSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL7571491 | 0.81 | NPC1 (0.67) | NPC1TSHRWDR5MEN1KMT2A | |
| SCHEMBL22005134 | 0.80 | NPC1 (0.66) | NPC1TSHRWDR5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |