Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.70 |
| ▸ | WDR5 | P61964 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | MYC | P01106 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ALPL | P05186 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 2/20 | 0.53 |
| ▸ | ACLY | P53396 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7571491 | 0.85 | NPC1 (0.67) | NPC1TSHRWDR5MEN1ALDH1A1 | |
| SCHEMBL4187686 | 0.85 | WDR5 (0.63) | NPC1TSHRWDR5MYCLMNA | |
| SCHEMBL7594909 | 0.85 | NPC1 (0.89) | NPC1TSHRWDR5MEN1ALDH1A1 | |
| SCHEMBL7571589 | 0.84 | LMNA (0.73) | NPC1TSHRWDR5MEN1ALDH1A1 | |
| SCHEMBL7589293 | 0.83 | NPC1 (0.72) | NPC1TSHRWDR5MEN1ALDH1A1 | |
| SCHEMBL7572911 | 0.82 | NPC1 (1.00) | NPC1TSHRWDR5MEN1ALDH1A1 | |
| SCHEMBL22095987 | 0.81 | SMN1; SMN2 (0.78) | NPC1TSHRMEN1ALDH1A1KMT2A | |
| SCHEMBL25450006 | 0.81 | NPC1 (0.62) | NPC1TSHRWDR5MEN1ALDH1A1 | |
| SCHEMBL30161354 | 0.81 | NPC1 (0.62) | NPC1TSHRWDR5MEN1ALDH1A1 | |
| SCHEMBL18341387 | 0.78 | MCL1 (0.60) | NPC1TSHRWDR5MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |