Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 7/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.58 |
| ▸ | RELA | Q04206 | 1/20 | 0.58 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.58 |
| ▸ | BRAF | P15056 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7594332 | 0.85 | ALDH1A1 (0.71) | ALDH1A1NPC1NFKBIARELAGLO1 | |
| SCHEMBL7590525 | 0.83 | NPC1 (0.63) | CCR2ALDH1A1NPC1KMT2ASMN1; SMN2 | |
| SCHEMBL7590993 | 0.83 | CCR2 (0.66) | CCR2ALDH1A1NPC1BRAFMEN1 | |
| SCHEMBL9930914 | 0.82 | CCR2 (0.77) | CCR2BRAFMEN1KMT2A | |
| SCHEMBL7570499 | 0.82 | BRAF (0.65) | CCR2ALDH1A1NPC1NFKBIARELA | |
| SCHEMBL9564525 | 0.81 | BRD4 (0.55) | CCR2ALDH1A1NPC1NFKBIARELA | |
| SCHEMBL9931078 | 0.79 | CCR2 (1.00) | CCR2BRAFMEN1KMT2A | |
| SCHEMBL7571210 | 0.79 | CCR2 (0.67) | CCR2ALDH1A1NPC1BRAFMEN1 | |
| SCHEMBL7573912 | 0.79 | CCR2 (0.70) | CCR2ALDH1A1BRAFMEN1KMT2A | |
| SCHEMBL9930692 | 0.79 | CCR2 (0.78) | CCR2BRAFMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |