Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 10/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | BRAF | P15056 | 1/20 | 0.54 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7571210 | 0.85 | CCR2 (0.67) | CCR2TP53NPC1ALDH1A1MEN1 | |
| SCHEMBL7578803 | 0.85 | TP53 (0.73) | CCR2TP53NPC1ALDH1A1MEN1 | |
| SCHEMBL9930362 | 0.83 | CCR2 (0.78) | CCR2TP53MEN1KMT2ABRAF | |
| SCHEMBL7590525 | 0.83 | NPC1 (0.63) | CCR2TP53NPC1ALDH1A1KMT2A | |
| SCHEMBL7573015 | 0.83 | CCR2 (0.64) | CCR2TP53NPC1ALDH1A1MEN1 | |
| SCHEMBL9930276 | 0.82 | CCR2 (0.77) | CCR2TP53BRAF | |
| SCHEMBL7594332 | 0.82 | ALDH1A1 (0.71) | TP53NPC1ALDH1A1MEN1KMT2A | |
| SCHEMBL9931241 | 0.81 | CCR2 (0.75) | CCR2TP53MEN1KMT2ABRAF | |
| SCHEMBL15359775 | 0.81 | TP53 (0.53) | CCR2TP53ALDH1A1MEN1KMT2A | |
| SCHEMBL15359878 | 0.80 | TP53 (0.52) | CCR2TP53NPC1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |