Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MGAM | O43451 | 1/20 | 0.45 |
| ▸ | SI | P14410 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6649337 | 0.84 | ALDH1A1 (0.50) | HDAC2LMNAALDH1A1GAAMGAM | |
| SCHEMBL8373001 | 0.83 | TSHR (0.55) | ALDH1A1GAAPKMMAPTTSHR | |
| SCHEMBL2770653 | 0.79 | CYP3A4 (0.44) | LMNAALDH1A1GAAMAPTTSHR | |
| SCHEMBL6541802 | 0.77 | ALOX15 (0.57) | HDAC2LMNAALDH1A1GAAMGAM | |
| SCHEMBL7496853 | 0.76 | PGR (0.55) | ALDH1A1PGR | |
| SCHEMBL7493059 | 0.76 | TAAR1 (0.51) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL6738366 | 0.76 | TSHR (0.76) | LMNAALDH1A1GAAMGAMSI | |
| SCHEMBL7001023 | 0.75 | GAA (0.56) | ALDH1A1GAAMAPTTSHRMEN1 | |
| SCHEMBL7142305 | 0.75 | ALDH1A1 (0.63) | HDAC2LMNAALDH1A1GAAMGAM | |
| SCHEMBL30360587 | 0.75 | ALDH1A1 (0.63) | HDAC2LMNAALDH1A1GAAMGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1175404-A1 | QUINAZOLINONE AND BENZOXAZINE DERIVATIVES AS PROGESTERONE RECEPTOR MODULATORS | American Home Products Corporation (US) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000066560-A1 | QUINAZOLINONE AND BENZOXAZINE DERIVATIVES AS PROGESTERONE RECEPTOR MODULATORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-11-09 | — | — | WO | disclosed |