Sugi Predict

Sugi Predict / Compounds / SCHEMBL757425

SCHEMBL757425

SCHEMBL757425

Nc1n[nH]c2ccc([N+](=O)[O-])cc12

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 3/20 0.63
▸ HPGD P15428 1/20 0.63
▸ CA12 O43570 1/20 0.53
▸ CA9 Q16790 1/20 0.53
▸ JAK2 O60674 3/20 0.51
▸ PDPK1 O15530 1/20 0.51
▸ TDP1 Q9NUW8 2/20 0.50
▸ NOS1 P29475 2/20 0.50
▸ POLB P06746 1/20 0.50
▸ MAOB P27338 1/20 0.50
▸ CNR2 P34972 3/20 0.49
▸ CDK2 P24941 2/20 0.49
▸ CSNK2A1 P68400 1/20 0.48
▸ CNR1 P21554 1/20 0.48
▸ GABRA1 P14867 1/20 0.48
▸ GABRG2 P18507 1/20 0.48
▸ GABRB3 P28472 1/20 0.48
▸ GABRA5 P31644 1/20 0.48
▸ GABRA2 P47869 1/20 0.48
▸ ALDH1A1 P00352 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2931498 0.86 JAK2 (0.51) MAPTHPGDCA12CA9JAK2
SCHEMBL29431208 0.86 JAK2 (0.51) MAPTHPGDCA12CA9JAK2
Tert-Butyl Formate SCHEMBL27967197 0.85 MAPT (0.49) MAPTHPGDCA12CA9JAK2
SCHEMBL6113793 0.83 MAPT (0.56) MAPTHPGDCA12CA9TDP1
SCHEMBL12193486 0.83 MAPT (0.63) MAPTHPGDCA12CA9NOS1
SCHEMBL27766963 0.82 GAA (0.51) MAPTHPGDCA12CA9JAK2
SCHEMBL27648257 0.82 MAPT (0.74) MAPTHPGDCA12CA9TDP1
SCHEMBL760760 0.81 MAPT (0.61) MAPTHPGDCA12CA9NOS1
SCHEMBL9489886 0.81 MAPT (0.61) MAPTHPGDCA12CA9NOS1
SCHEMBL760614 0.81 MAPT (0.61) MAPTHPGDCA12CA9NOS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 134 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4648630-B2 — — 2011-03-09 — — JP claimed
CN-101962365-A Aminoindazole derivatives as protein-kinase inhibitors AVENTIS PHARMA SA 2011-02-02 — — CN claimed
CN-1656078-A Aminoindazole derivatives as protein kinase inhibitors AVENTIS PHARMA SA (FR) 2005-08-17 — — CN claimed
US-20040014802-A1 Aminoindazole derivatives and intermediates, preparation thereof, and pharmaceutical compositions thereof AVENTIS PHARMA S.A. (FR) 2004-01-22 — — US claimed
WO-2025001864-A1 FASCIN INHIBITORS Beijing Double-Crane Runchuang Technology Co., Ltd. (CN) 2025-01-02 — — WO disclosed
US-20230077268-A1 INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS E-SCAPE BIO, INC. 2023-03-09 — — US disclosed
US-11427558-B1 Indazoles and azaindazoles as LRRK2 inhibitors ESCAPE Bio, Inc. (US) 2022-08-30 — — US disclosed
EP-3997081-A1 INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS Escape Bio, Inc. (US) 2022-05-18 — — EP disclosed
CN-114450274-A Indazoles and azaindazoles as LRRK2 inhibitors 伊斯凯普生物公司 2022-05-06 — — CN disclosed
WO-2021007477-A1 INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS E-SCAPE BIO, INC. (US) 2021-01-14 — — WO disclosed
US-10858321-B2 Composition for inducing cell reprogramming GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2020-12-08 — — US disclosed
CN-106794172-B Composition for inducing cell reprogramming 光州科学技术院 2020-03-17 — — CN disclosed
US-4113720-A Disperse azo dye with diaminopyrimidine coupling component BASF AKTIENGESELLSCHAFT (DE) 1978-09-12 — — US disclosed
US-4084053-A YELLOW AND ORANGE DYES, PYRIMIDINO(4',5':5,6)-1,2,4-TRIAZINO(4,3-BETA)INDAZOLES CIBA-GEIGY CORPORATION (US) 1978-04-11 — — US disclosed
US-4051252-A ANALGESIC, ANTIINFLAMMATORY, ANTIPYRETIC BAYER AKTIENGESELLSCHAFT (DT) 1977-09-27 — — US disclosed
US-4043751-A BENZENE OR NAPHTHALENE NUCLEUS PRODUITS CHIMIQUES UGINE KUHLMANN (FR) 1977-08-23 — — US disclosed
US-4042578-A POLYESTERS BADISCHE ANILIN- & SODA-FABRIK AKTIENGESELLSCHAFT (DT) 1977-08-16 — — US disclosed
US-4041025-A FOR HYDROPHOBIC FIBERS SUCH AS POLYESTERS, YELLOW TO BLUE-GREEN SHADES BASF AKTIENGESELLSCHAFT (DT) 1977-08-09 — — US disclosed
US-4017479-A Cationic indazole-azo-5-amino pyrazole dyestuffs CIBA-GEIGY AG (CH) 1977-04-12 — — US disclosed
US-3985726-A DYEING AND PRINTING LEATHER, WOOL, SILK AND SYNTHETIC FIBERS CIBA-GEIGY AG (CH) 1976-10-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040014802-A1 Aminoindazole derivatives and intermediates, preparation thereof, and pharmaceutical compositions thereof CYP2C8, NR0B2, NR2C2 MAPT 4462/4885HPGD 2039/4885CA12 3569/4885
US-11427558-B1 Indazoles and azaindazoles as LRRK2 inhibitors LRRK2, PARK7, GDI2 MAPT 66/4885HPGD 2992/4885CA12 4879/4885
US-10858321-B2 Composition for inducing cell reprogramming MCL1, IRF3, STING1 MAPT 2961/4885HPGD 3416/4885CA12 4007/4885
US-20230077268-A1 INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS LRRK2, PARK7, GDI2 MAPT 66/4885HPGD 2992/4885CA12 4879/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.