Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7575243 | 0.84 | ALDH1A1 (0.40) | MAPTSMN1; SMN2TP53ALDH1A1GAA | |
| SCHEMBL13922073 | 0.75 | TUBB4A (0.43) | MAPTSMN1; SMN2TP53ALDH1A1GAA | |
| SCHEMBL7581044 | 0.75 | CDK2 (0.42) | MAPTALDH1A1GAACDK2KDM4E | |
| SCHEMBL31238363 | 0.73 | MAPT (0.48) | MAPTALDH1A1GAACDK2KDM4E | |
| SCHEMBL7572546 | 0.72 | KDM4E (0.47) | MAPTSMN1; SMN2TP53ALDH1A1GAA | |
| SCHEMBL13922083 | 0.71 | KDM4E (0.37) | MAPTALDH1A1GAAHPGDKDM4E | |
| SCHEMBL9908164 | 0.68 | MEN1 (0.39) | MAPTSMN1; SMN2ALDH1A1GAAHPGD | |
| SCHEMBL7561134 | 0.68 | CA12 (0.59) | MAPTSMN1; SMN2ALDH1A1KDM4ERAB9A | |
| SCHEMBL428389 | 0.67 | RAB9A (0.53) | MAPTSMN1; SMN2ALDH1A1GAAHPGD | |
| Hydrochloric Acid SCHEMBL29099350 | 0.66 | RAB9A (0.51) | MAPTSMN1; SMN2ALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686147-B1 | NOVEL 2,2'-BI-1H-PYRROLE DERIVATIVES WITH IMMUNOSUPPRESSANT ACTIVITY | PHARMACIA ITALIA SPA (IT) | 2002-09-25 | — | — | EP | disclosed |
| EP-1241162-A1 | 2,2'-bi-1H-pyrrole derivatives with immunosuppressant activity | Pharmacia Italia S.p.A. (IT) | 2002-09-18 | — | — | EP | disclosed |
| US-5691334-A | IMMUNOMODULATORS FOR SKIN GRAFTS, AUTOIMMUNE AND FOR ORGAN TRANSPLANTS | PHARMACIA & UPJOHN S.P.A. (IT) | 1997-11-25 | — | — | US | disclosed |
| EP-0686147-A1 | NOVEL 2,2'-BI-1H-PYRROLE DERIVATIVES WITH IMMUNOSUPPRESSANT ACTIVITY | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-12-13 | — | — | EP | disclosed |
| WO-1995017381-A1 | NOVEL 2,2'-BI-1H-PYRROLE DERIVATIVES WITH IMMUNOSUPPRESSANT ACTIVITY | PHARMACIA S.P.A. (IT) | 1995-06-29 | — | — | WO | disclosed |