Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 6/20 | 0.83 |
| ▸ | KDR | P35968 | 10/20 | 0.70 |
| ▸ | RET | P07949 | 9/20 | 0.70 |
| ▸ | KIF5B | P33176 | 7/20 | 0.70 |
| ▸ | RAF1 | P04049 | 3/20 | 0.64 |
| ▸ | BRAF | P15056 | 3/20 | 0.64 |
| ▸ | EGFR | P00533 | 3/20 | 0.60 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.59 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.59 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7575453 | 0.86 | SRC (0.61) | SRCKDRRETKIF5BEGFR | |
| SCHEMBL18158610 | 0.82 | RET (1.00) | SRCKDRRETKIF5BRAF1 | |
| SCHEMBL6018368 | 0.82 | EGFR (0.68) | SRCKDRRETKIF5BEGFR | |
| SCHEMBL907182 | 0.81 | KDR (0.77) | KDRRETKIF5BRAF1BRAF | |
| Hydrochloric Acid SCHEMBL907165 | 0.81 | EGFR (0.67) | SRCKDRRETKIF5BEGFR | |
| SCHEMBL7573786 | 0.81 | SRC (0.80) | SRCKDRRETKIF5BEGFR | |
| SCHEMBL2456254 | 0.80 | RET (0.72) | KDRRETKIF5BEGFR | |
| SCHEMBL7574178 | 0.79 | SRC (0.77) | SRCKDRRETKIF5BEGFR | |
| SCHEMBL3274759 | 0.79 | SRC (0.77) | SRCKDRRETKIF5BRAF1 | |
| SCHEMBL7580342 | 0.79 | SRC (0.76) | SRCKDRRETKIF5BEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002092579-A1 | 4-ANILINOQUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2002-11-21 | — | — | WO | disclosed |
| WO-2002092577-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2002-11-21 | — | — | WO | disclosed |