Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 3/20 | 0.66 |
| ▸ | STS | P08842 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | CASP3 | P42574 | 1/20 | 0.55 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.55 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.55 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.55 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.55 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.54 |
| ▸ | CSNK2B | P67870 | 4/20 | 0.54 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.54 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8493156 | 0.87 | ALOX15 (0.66) | ALOX15MAPTCYP3A4HPGDTP53 | |
| SCHEMBL21623585 | 0.83 | MAPT (0.55) | ALOX15MAPTCYP3A4NPC1RAB9A | |
| SCHEMBL23334588 | 0.81 | MAPT (0.73) | ALOX15STSMAPTCYP3A4NPC1 | |
| SCHEMBL12882254 | 0.80 | ALOX15 (0.56) | ALOX15STSMAPTNPC1RAB9A | |
| SCHEMBL7574959 | 0.78 | STS (0.64) | ALOX15STSMAPTCYP3A4NPC1 | |
| SCHEMBL13656194 | 0.78 | ALOX15 (0.54) | ALOX15STSMAPTNPC1RAB9A | |
| SCHEMBL22950970 | 0.77 | CSNK2A2 (0.62) | ALOX15MAPTCYP3A4NPC1RAB9A | |
| SCHEMBL12867892 | 0.77 | ALOX15 (0.57) | ALOX15STSMAPTCYP3A4NPC1 | |
| SCHEMBL8870443 | 0.77 | MAPT (0.55) | ALOX15MAPTCYP3A4NPC1RAB9A | |
| SCHEMBL11563475 | 0.75 | ALOX15 (0.51) | ALOX15STSMAPTHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6482950-B1 | Squarylium compounds, and processes and intermediates for the synthesis of these compounds | POLAROID CORPORATION | 2002-11-19 | — | — | US | disclosed |
| EP-1070059-B1 | CHROMANONE AND THIOCHROMANONE DERIVATIVES | NOVARTIS AG (CH) | 2002-09-25 | — | — | EP | disclosed |
| US-6346626-B1 | DRUGS FOR TREATMENT OF SKIN DISORDERS SUCH AS ACNE, SEBORRHEA, ANDROGENIC ALOPECIA AND HIRSUTISM, OR IN THE TOPICAL TREATMENT OF SQUAMOUS CELL CARCINOMA | NOVARTIS AG (CH) | 2002-02-12 | — | — | US | disclosed |
| EP-1070059-A1 | CHROMANONE AND THIOCHROMANONE DERIVATIVES | Novartis AG (CH) | 2001-01-24 | — | — | EP | disclosed |
| US-5977351-A | Benzpyrylium squarylium and croconylium dyes, and processes for their preparation and use | POLAROID CORPORATION (US) | 1999-11-02 | — | — | US | disclosed |
| WO-1999052890-A1 | CHROMANONE AND THIOCHROMANONE DERIVATIVES | NOVARTIS AG (CH) | 1999-10-21 | — | — | WO | disclosed |
| US-5919950-A | SYNTHESIS OF SQUARATE DYES | POLAROID CORPORATION (US) | 1999-07-06 | — | — | US | disclosed |
| US-5795981-A | DYES, OR CHEMICAL INTERMEDIATES THEREOF | POLAROID CORPORATION (US) | 1998-08-18 | — | — | US | disclosed |
| US-5656750-A | Processes for the preparation of squarylium dyes | POLAROID CORPORATION (US) | 1997-08-12 | — | — | US | disclosed |
| US-5627014-A | COMPOSITIONS FOR ABSORBERS OF HEAT WHILE COLORING | POLAROID CORPORATION (US) | 1997-05-06 | — | — | US | disclosed |
| EP-0613422-B1 | SQUARYLIUM DYES | POLAROID CORP (US) | 1996-08-21 | — | — | EP | disclosed |
| US-5492795-A | ABSORBING IR RAD TO GENERATE HEAT EFFECTING COLOR CHANGE IN SENSITIVE MATERIAL; AMINOCYCLOBUTENE BONDED TO PYRYLIUM, BENZPYRYLIUM. SELENOPYRYLIUM, BENZTHIOPYRYLIUM AND THIO-PYRYLIUM RINGS | POLAROID CORPORATION (US) | 1996-02-20 | — | — | US | disclosed |
| US-5354873-A | Pyrylium, thiopyrylium and seleno dyes including a 1,2-dioxo-3 -aminocyclobut-3-ene group; near infrared absorption; increased solubility; charge transfer compounds; thermochromic | POLAROID CORPORATION (US) | 1994-10-11 | — | — | US | disclosed |