Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 4/20 | 0.52 |
| ▸ | MMP13 | P45452 | 4/20 | 0.52 |
| ▸ | MMP9 | P14780 | 3/20 | 0.52 |
| ▸ | MMP3 | P08254 | 1/20 | 0.50 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.42 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.42 |
| ▸ | MCOLN1 | Q9GZU1 | 1/20 | 0.42 |
| ▸ | USP5 | P45974 | 2/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4426623 | 0.79 | MMP3 (0.54) | MMP2MMP13MMP9MMP3USP5 | |
| SCHEMBL8343032 | 0.77 | MMP2 (0.53) | MMP2MMP13MMP9MMP3CA12 | |
| SCHEMBL6417993 | 0.77 | MMP3 (0.52) | MMP2MMP13MMP9MMP3USP5 | |
| SCHEMBL4434657 | 0.76 | MMP2 (0.56) | MMP2MMP13MMP9MMP3USP5 | |
| SCHEMBL6413210 | 0.75 | MMP3 (0.65) | MMP2MMP13MMP9MMP3 | |
| SCHEMBL6414008 | 0.75 | MMP3 (0.65) | MMP2MMP13MMP9MMP3 | |
| SCHEMBL6413216 | 0.75 | MMP3 (0.65) | MMP2MMP13MMP9MMP3 | |
| SCHEMBL2026104 | 0.75 | BCAT1 (0.55) | MMP2MMP13MMP9CA12CA1 | |
| SCHEMBL15801111 | 0.74 | NPC1 (0.54) | MMP2MMP13MMP9SLC18A3NPC1 | |
| SCHEMBL8343036 | 0.74 | CA1 (0.63) | MMP2MMP13MMP9MMP3CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874836-B1 | SULFONAMIDE INHIBITORS OF MATRIX METALLOPROTEINASES | WARNER LAMBERT CO (US) | 2002-10-09 | — | — | EP | disclosed |
| CN-1310629-A | Combined administration of ACAT and MMP inhibitors for the treatment of atherosclerotic lesions | WARNER LAMBERT CO (US) | 2001-08-29 | — | — | CN | disclosed |
| US-6153612-A | Sulfonamide inhibitors of matrix metalloproteinases | WARNER-LAMBERT COMPANY (US) | 2000-11-28 | — | — | US | disclosed |