Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAALAD2 | Q9Y3Q0 | 6/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.47 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.47 |
| ▸ | GGH | Q92820 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7575988 | 1.00 | NAALAD2 (0.47) | NAALAD2FOLH1RIMKLAGGHGAA | |
| SCHEMBL4456734 | 0.83 | PPARG (0.37) | FOLH1GAA | |
| SCHEMBL4455175 | 0.83 | PPARG (0.37) | FOLH1GAA | |
| SCHEMBL6558181 | 0.82 | PKLR (0.40) | GAA | |
| SCHEMBL6558177 | 0.82 | PKLR (0.40) | GAA | |
| SCHEMBL20533611 | 0.80 | MMP2 (0.42) | FOLH1MMP9 | |
| SCHEMBL4455180 | 0.79 | FOLH1 (0.38) | FOLH1GAAKDM4E | |
| SCHEMBL31052801 | 0.79 | GRN (0.46) | KDM4E | |
| SCHEMBL13760292 | 0.79 | KDM4E (0.41) | FOLH1GAAKDM4E | |
| SCHEMBL5828020 | 0.79 | KDM4E (0.41) | FOLH1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002101391-A2 | METHOD OF USE | ELI LILLY AND COMPANY (US) | 2002-12-19 | — | — | WO | disclosed |
| EP-0722440-A1 | PYRIMIDINYL-GLUTAMIC ACID DERIVATIVES | ELI LILLY AND COMPANY (US) | 1996-07-24 | — | — | EP | disclosed |
| EP-0722440-A1 | PYRIMIDINYL-GLUTAMIC ACID DERIVATIVES | ELI LILLY AND COMPANY (US) | 1996-07-24 | — | — | EP | disclosed |
| EP-0722440-A4 | PYRIMIDINYL-GLUTAMIC ACID DERIVATIVES | LILLY CO ELI (US) | 1996-06-04 | — | — | EP | disclosed |
| EP-0722440-A4 | PYRIMIDINYL-GLUTAMIC ACID DERIVATIVES | LILLY CO ELI (US) | 1996-06-04 | — | — | EP | disclosed |
| US-5426110-A | Inhibiting dihydrofolate reductase in mammals and treating susceptible reoplasms | ELI LILLY AND COMPANY (US) | 1995-06-20 | — | — | US | disclosed |
| US-5426110-A | Inhibiting dihydrofolate reductase in mammals and treating susceptible reoplasms | ELI LILLY AND COMPANY (US) | 1995-06-20 | — | — | US | disclosed |
| US-5426110-A | Inhibiting dihydrofolate reductase in mammals and treating susceptible reoplasms | ELI LILLY AND COMPANY (US) | 1995-06-20 | — | — | US | disclosed |
| WO-1995009845-A1 | PYRIMIDINYL-GLUTAMIC ACID DERIVATIVES | ELI LILLY AND COMPANY (US) | 1995-04-13 | — | — | WO | disclosed |
| WO-1995009845-A1 | PYRIMIDINYL-GLUTAMIC ACID DERIVATIVES | ELI LILLY AND COMPANY (US) | 1995-04-13 | — | — | WO | disclosed |
| CN-1014895-B | Process for preparation of 4(3H)-oxo-5,6,7,8-tetrahydropyrido-[2,3-d] pyrimidine derivatives | UNIV PRINCETON (US) | 1991-11-27 | — | — | CN | disclosed |
| CN-87104596-A | 4 (3H)-oxos-5,6,7,8-tetrahydropyridine are the preparation method of [2,3-d] pyrimidine derivatives also | — | 1988-01-20 | — | — | CN | disclosed |