SCHEMBL7576884

SCHEMBL7576884

O=C(O)C(Nc1ccc(F)c(F)c1F)c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.43
TAS1R3 Q7RTX0 1/20 0.42
TAS1R1 Q7RTX1 1/20 0.42
TAS1R2 Q8TE23 1/20 0.42
ALPL P05186 1/20 0.40
ALPI P09923 1/20 0.40
ALPG P10696 1/20 0.40
ULK1 O75385 1/20 0.38
EPHX2 P34913 5/20 0.38
CYP2D6 P10635 2/20 0.38
MEN1 O00255 1/20 0.38
CYP1A2 P05177 1/20 0.38
POLB P06746 1/20 0.38
CYP2C9 P11712 1/20 0.38
HPGD P15428 1/20 0.38
ALOX12 P18054 1/20 0.38
CYP2C19 P33261 1/20 0.38
KMT2A Q03164 1/20 0.38
SRC P12931 1/20 0.37
GAA P10253 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7578154 0.87 GAA (0.43) ALDH1A1CYP2D6MEN1KMT2AGAA
SCHEMBL16664407 0.81 GAA (0.50) ALDH1A1CYP2D6MEN1KMT2AGAA
SCHEMBL13241014 0.81 GAA (0.50) ALDH1A1CYP2D6MEN1KMT2AGAA
SCHEMBL2484664 0.81 GAA (0.50) ALDH1A1CYP2D6MEN1KMT2AGAA
SCHEMBL7577550 0.80 PPARG (0.51) ALDH1A1TAS1R3TAS1R1ULK1MEN1
Hydrochloric Acid SCHEMBL2486567 0.80 GAA (0.49) ALDH1A1MEN1CYP1A2CYP2C9CYP2C19
SCHEMBL7582068 0.79 ULK1 (0.54) ALDH1A1TAS1R3TAS1R1TAS1R2ULK1
SCHEMBL2483532 0.79 ULK1 (0.47) ALDH1A1ULK1MEN1KMT2AGAA
SCHEMBL12071889 0.79 ULK1 (0.47) ALDH1A1ULK1MEN1KMT2AGAA
Hydrochloric Acid SCHEMBL1695681 0.78 ULK1 (0.46) ALDH1A1ULK1MEN1KMT2AGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1242069-A2 ALBUMIN-BINDING COMPOUNDS THAT PREVENT NONENZYMATIC GLYCATION AND THAT MAY BE USED FOR TREATMENT OF GLYCATION-RELATED PATHOLOGIES EXOCELL, INC. (US) 2002-09-25 EP disclosed
WO-2001003684-A2 ALBUMIN-BINDING COMPOUNDS THAT PREVENT NONENZYMATIC GLYCATION AND THAT MAY BE USED FOR TREATMENT OF GLYCATION-RELATED PATHOLOGIES EXOCELL, INC. (US) 2001-01-18 WO disclosed