Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.72 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.72 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.72 |
| ▸ | CCND1 | P24385 | 1/20 | 0.72 |
| ▸ | CDK2 | P24941 | 1/20 | 0.72 |
| ▸ | CDK7 | P50613 | 1/20 | 0.72 |
| ▸ | CCNH | P51946 | 1/20 | 0.72 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.72 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.71 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.60 |
| ▸ | APP | P05067 | 1/20 | 0.60 |
| ▸ | ACLY | P53396 | 1/20 | 0.56 |
| ▸ | TYMS | P04818 | 1/20 | 0.54 |
| ▸ | S100A9 | P06702 | 4/20 | 0.52 |
| ▸ | SGK1 | O00141 | 4/20 | 0.52 |
| ▸ | PGR | P06401 | 2/20 | 0.49 |
| ▸ | IL1RN | P18510 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7571716 | 0.87 | CDK1 (0.77) | CDK1CCNB1CCNA2CCND1CDK2 | |
| SCHEMBL7593518 | 0.85 | ACLY (0.61) | CDK1CCNB1CCNA2CCND1CDK2 | |
| SCHEMBL31060131 | 0.84 | CDK1 (1.00) | CDK1CCNB1CCNA2CCND1CDK2 | |
| SCHEMBL2162763 | 0.82 | CDK1 (0.54) | CDK1CCNB1CCNA2CCND1CDK2 | |
| SCHEMBL7569616 | 0.80 | CDK1 (0.68) | CDK1CCNB1CCNA2CCND1CDK2 | |
| SCHEMBL2841655 | 0.80 | TDP1 (0.61) | CDK1CCNB1CCNA2CCND1CDK2 | |
| SCHEMBL7573932 | 0.78 | CDK1 (0.74) | CDK1CCNB1CCNA2CCND1CDK2 | |
| SCHEMBL7573900 | 0.77 | CDK1 (0.72) | CDK1CCNB1CCNA2CCND1CDK2 | |
| SCHEMBL6205865 | 0.76 | TDP1 (0.57) | CDK1CCNB1CCNA2CCND1CDK2 | |
| SCHEMBL6205861 | 0.76 | TDP1 (0.57) | CDK1CCNB1CCNA2CCND1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |