Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.54 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.54 |
| ▸ | CCND1 | P24385 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | CDK7 | P50613 | 1/20 | 0.54 |
| ▸ | CCNH | P51946 | 1/20 | 0.54 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.54 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | ACLY | P53396 | 1/20 | 0.53 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.50 |
| ▸ | TYMS | P04818 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | SGK1 | O00141 | 5/20 | 0.44 |
| ▸ | S100A9 | P06702 | 4/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7579927 | 0.82 | CDK1 (0.72) | CDK1CCNB1CCNA2CCND1CDK2 | |
| SCHEMBL2157782 | 0.81 | PTPN2 (0.53) | TDP1CNR1MEN1KMT2A | |
| SCHEMBL2157528 | 0.81 | PFKFB3 (0.52) | ACLYPFKFB3CNR1PGRMEN1 | |
| SCHEMBL2158700 | 0.80 | ITGA1 (0.56) | ACLYCNR1PGRMEN1POLB | |
| SCHEMBL2158501 | 0.79 | CNR1 (0.49) | CNR1PGRMEN1POLBKMT2A | |
| SCHEMBL2157624 | 0.78 | CNR1 (0.49) | CDK1CCNB1CCNA2CDK2CDK7 | |
| SCHEMBL2158687 | 0.77 | CNR1 (0.42) | ACLYCNR1PGRMEN1POLB | |
| SCHEMBL2158458 | 0.75 | PGR (0.55) | ACLYCNR1PGRMEN1KMT2A | |
| SCHEMBL2158054 | 0.74 | ALDH1A1 (0.52) | TDP1MEN1KMT2A | |
| SCHEMBL2158492 | 0.74 | USP2 (0.49) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7985769-B2 | Compounds and methods for the treatment or prevention of Flavivirus infections | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-07-26 | — | — | US | disclosed |
| US-20060142347-A1 | Compounds and methods for the treatment or prevention of Flavivirus infections | VERTEX PHARMACEUTICALS (CANADA) INCORPORATED (CA) | 2006-06-29 | — | — | US | disclosed |
| US-6881741-B2 | Compounds and methods for the treatment or prevention of Flavivirus infections | VIROCHEM PHARMA INC. (CA) | 2005-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142347-A1 | Compounds and methods for the treatment or prevention of Flavivirus infections | HAVCR2, ZC3HAV1, MAVS | CDK1 3925/4885CCNB1 4249/4885CCNA2 4778/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.