Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | ACLY | P53396 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2518669 | 0.91 | KMT2A (0.63) | KMT2AMEN1MAPK1ALDH1A1PTGES2 | |
| SCHEMBL13577033 | 0.88 | KMT2A (0.64) | KMT2AMEN1MAPK1ALDH1A1NPC1 | |
| SCHEMBL3611184 | 0.84 | ALDH1A1 (0.80) | KMT2AMEN1MAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4192352 | 0.84 | NPC1 (0.58) | KMT2AMEN1MAPK1ALDH1A1PTGES2 | |
| SCHEMBL7586724 | 0.84 | NPC1 (0.68) | KMT2AMEN1MAPK1ALDH1A1NPC1 | |
| SCHEMBL13146531 | 0.83 | PGR (0.67) | KMT2AMEN1MAPK1PTGES2ACLY | |
| SCHEMBL2514752 | 0.82 | KMT2A (0.57) | KMT2AMEN1MAPK1ALDH1A1PTGES2 | |
| SCHEMBL16235476 | 0.81 | CCR2 (0.63) | KMT2AMEN1MAPK1ALDH1A1 | |
| SCHEMBL1035847 | 0.81 | MEN1 (1.00) | KMT2AMEN1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL28450939 | 0.80 | MEN1 (0.68) | KMT2AMEN1MAPK1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |