Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 6/20 | 0.61 |
| ▸ | EBP | Q15125 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.57 |
| ▸ | ESR1 | P03372 | 6/20 | 0.55 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.55 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.53 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.53 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7571695 | 0.99 | LTA4H (0.62) | LTA4HEBPSIGMAR1ESR1ESR2 | |
| SCHEMBL8504413 | 0.93 | EBP (0.64) | LTA4HEBPSIGMAR1ESR1ESR2 | |
| SCHEMBL7580135 | 0.92 | ESR1 (0.67) | LTA4HEBPSIGMAR1ESR1ESR2 | |
| SCHEMBL7582532 | 0.91 | ESR1 (0.65) | LTA4HEBPSIGMAR1ESR1ESR2 | |
| SCHEMBL8015671 | 0.91 | EBP (0.67) | LTA4HEBPSIGMAR1ESR1ESR2 | |
| SCHEMBL7576301 | 0.86 | ESR1 (0.74) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL7574747 | 0.85 | ESR1 (0.73) | ESR1ESR2PSMB1PSMB5PSMB2 | |
| SCHEMBL9993383 | 0.84 | EBP (0.74) | LTA4HEBPSIGMAR1ESR1ESR2 | |
| SCHEMBL8003918 | 0.83 | LTA4H (0.60) | LTA4HEBPSIGMAR1ESR1ESR2 | |
| SCHEMBL7574347 | 0.83 | LTA4H (0.52) | LTA4HEBPSIGMAR1ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5994370-A | ESTROGEN RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 1999-11-30 | — | — | US | claimed |
| EP-0873992-B1 | Indene compounds having activity as SERMs | LILLY CO ELI (US) | 2002-09-25 | — | — | EP | disclosed |
| US-5994370-A | ESTROGEN RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 1999-11-30 | — | — | US | disclosed |
| EP-0873992-A1 | Indene compounds having activity as SERMs | ELI LILLY AND COMPANY (US) | 1998-10-28 | — | — | EP | disclosed |