Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.34 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7584411 | 0.91 | KMT2A (0.32) | BACE1ALDH1A1 | |
| SCHEMBL7584371 | 0.90 | BACE1 (0.31) | BACE1 | |
| SCHEMBL7584231 | 0.90 | ELANE (0.33) | BACE1 | |
| SCHEMBL7581190 | 0.89 | BACE1 (0.31) | BACE1 | |
| SCHEMBL7581043 | 0.89 | BACE1 (0.31) | BACE1 | |
| SCHEMBL7589796 | 0.89 | ALDH1A1 (0.32) | BACE1ALDH1A1 | |
| SCHEMBL7582473 | 0.89 | BACE1 (0.32) | BACE1 | |
| SCHEMBL7584647 | 0.88 | OPRM1 (0.31) | BACE1 | |
| SCHEMBL7584854 | 0.88 | BACE1 (0.30) | BACE1 | |
| SCHEMBL7589838 | 0.88 | BACE1 (0.36) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183252-B2 | Heterocyclic aspartyl protease inhibitors | SCHERING CORPORATION (US) | 2012-05-22 | — | — | US | disclosed |