Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 known ✓ | P11362 | 1/20 | 0.43 |
| ▸ | FGFR2 known ✓ | P21802 | 1/20 | 0.43 |
| ▸ | FGFR4 known ✓ | P22455 | 1/20 | 0.43 |
| ▸ | FGFR3 known ✓ | P22607 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7576463 | 0.92 | HDAC4 (0.44) | HDAC4HDAC2HDAC8ABL1ABCB1 | |
| SCHEMBL7574616 | 0.91 | HDAC4 (0.51) | HDAC4HDAC2HDAC8ABL1ABCB1 | |
| SCHEMBL4654653 | 0.87 | HDAC4 (0.41) | HDAC4HDAC2HDAC8ABL1ABCB1 | |
| SCHEMBL4655793 | 0.85 | HDAC4 (0.47) | HDAC4HDAC2HDAC8ABL1ABCB1 | |
| Trifluoromethanesulfonic Acid SCHEMBL387254 | 0.85 | HDAC4 (0.47) | HDAC4HDAC2HDAC8ABL1ABCB1 | |
| SCHEMBL145569 | 0.85 | ABL1 (0.60) | HDAC4HDAC2HDAC8ABL1ABCB1 | |
| SCHEMBL5707388 | 0.84 | PPARA (0.41) | HDAC4HDAC2HDAC8MAPTKDM4E | |
| Hydrochloric Acid SCHEMBL7696229 | 0.84 | ABL1 (0.58) | HDAC4HDAC2HDAC8ABL1ABCB1 | |
| SCHEMBL760070 | 0.82 | MEN1 (0.44) | HDAC4HDAC2HDAC8ABL1ABCB1 | |
| SCHEMBL4654732 | 0.82 | HDAC4 (0.43) | HDAC4HDAC2HDAC8ABL1ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020196896-A1 | Exposure method, exposure apparatus, X-ray mask, semiconductor device and microstructure | MITSUBISHI DENKI KABUSHIKI KAISHA (JP) | 2002-12-26 | — | — | US | disclosed |
| EP-1193553-A2 | Exposure method, exposure apparatus, x-ray mask, semiconductor device and microstructure | MITSUBISHI DENKI KABUSHIKI KAISHA (JP) | 2002-04-03 | — | — | EP | disclosed |