Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 15/20 | 0.43 |
| ▸ | DRD3 | P35462 | 15/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7583638 | 0.89 | DRD2 (0.44) | DRD2DRD3MAPT | |
| SCHEMBL7587283 | 0.86 | DRD2 (0.42) | DRD2DRD3MAPTALDH1A1 | |
| SCHEMBL7588002 | 0.83 | HTR2C (0.40) | DRD2DRD3HTR2AHTR2CHTR2B | |
| SCHEMBL7583440 | 0.83 | HTR2C (0.38) | DRD2DRD3HTR2AHTR2CHTR2B | |
| SCHEMBL7591745 | 0.82 | HTR2C (0.39) | DRD2DRD3HTR2AHTR2CHTR2B | |
| SCHEMBL7585550 | 0.82 | KDM1A (0.47) | HTR2AHTR2CHTR2B | |
| SCHEMBL7589890 | 0.82 | KMT2A (0.41) | HTR2AHTR2CHTR2BALDH1A1KMT2A | |
| SCHEMBL7586732 | 0.81 | HTR2C (0.37) | DRD2DRD3HTR2AHTR2CHTR2B | |
| SCHEMBL7583723 | 0.81 | NAAA (0.37) | DRD2DRD3HTR2AHTR2CHTR2B | |
| Ethane SCHEMBL7584566 | 0.76 | HTR2A (0.38) | DRD2DRD3HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | claimed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | claimed |
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| US-5849912-A | Biphenyl derivatives | EISAI CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |