Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.37 |
| ▸ | HTR2A | P28223 | 4/20 | 0.37 |
| ▸ | HTR2B | P41595 | 4/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | DRD3 | P35462 | 3/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | HTR1E | P28566 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HTR5A | P47898 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7588002 | 0.92 | HTR2C (0.40) | HTR2CHTR2AHTR2BHTR7NAAA | |
| SCHEMBL7583723 | 0.90 | NAAA (0.37) | HTR2CHTR2AHTR2BHTR7NAAA | |
| SCHEMBL7583440 | 0.87 | HTR2C (0.38) | HTR2CHTR2AHTR2BHTR7DRD2 | |
| SCHEMBL7585550 | 0.86 | KDM1A (0.47) | HTR2CHTR2AHTR2BHTR7NAAA | |
| SCHEMBL7591745 | 0.84 | HTR2C (0.39) | HTR2CHTR2AHTR2BHTR7DRD2 | |
| SCHEMBL7589890 | 0.84 | KMT2A (0.41) | HTR2CHTR2AHTR2BALDH1A1 | |
| SCHEMBL7583638 | 0.83 | DRD2 (0.44) | DRD2DRD3CYP1A2CYP2C19 | |
| SCHEMBL7582903 | 0.81 | DRD2 (0.43) | HTR2CHTR2AHTR2BDRD2DRD3 | |
| SCHEMBL7587283 | 0.81 | DRD2 (0.42) | DRD2DRD3HTR6ALDH1A1 | |
| SCHEMBL5240098 | 0.78 | PDE4B (0.43) | HTR2CHTR2AHTR2BPDE4BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | claimed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | claimed |
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| US-5849912-A | Biphenyl derivatives | EISAI CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |