Propaquizafop

Propaquizafop

SCHEMBL7583253

CC(C)=NOCCOC(=O)[C@@H](C)Oc1ccc(Oc2cnc3cc(Cl)ccc3n2)cc1.CCOc1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-]

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.42
LMNA P02545 2/20 0.42
HPGD P15428 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
TP53 P04637 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
ALOX15 P16050 1/20 0.42
NFKB1 P19838 1/20 0.42
HIF1A Q16665 1/20 0.42
GMNN O75496 1/20 0.42
ALDH1A1 P00352 1/20 0.42
APEX1 P27695 1/20 0.42
PMP22 Q01453 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
MEN1 O00255 5/20 0.40
KMT2A Q03164 5/20 0.40
TDP1 Q9NUW8 3/20 0.40
TTR P02766 1/20 0.40
PPOX P50336 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Propaquizafop SCHEMBL7579174 0.92 MEN1 (0.51) MAPTLMNAHPGDSMN1; SMN2TP53
Propaquizafop SCHEMBL7584000 0.90 TDP1 (0.41) MAPTLMNAHPGDSMN1; SMN2TP53
Quizalofop SCHEMBL7580307 0.88 MEN1 (0.47) MAPTLMNAHPGDSMN1; SMN2TP53
Propaquizafop SCHEMBL7578027 0.84 TDP1 (0.53) MAPTLMNAHPGDSMN1; SMN2TP53
Propaquizafop SCHEMBL7584108 0.83 TP53 (0.42) MAPTLMNAHPGDSMN1; SMN2TP53
SCHEMBL10614657 0.82 MEN1 (0.54) MAPTLMNAHPGDSMN1; SMN2ALDH1A1
Propaquizafop SCHEMBL7582078 0.82 TP53 (0.43) MAPTLMNAHPGDSMN1; SMN2TP53
Propaquizafop SCHEMBL9136963 0.80 MAPT (0.61) MAPTLMNAHPGDSMN1; SMN2TP53
Propaquizafop SCHEMBL43925 0.80 MAPT (0.61) MAPTLMNAHPGDSMN1; SMN2TP53
Propaquizafop SCHEMBL54333 0.80 MAPT (0.61) MAPTLMNAHPGDSMN1; SMN2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020004457-A1 Herbicidal composition SYNGENTA PARTICIPATIONS AG (CH) 2002-01-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020004457-A1 Herbicidal composition PPOX, ALAD, DDT MAPT 1092/4885LMNA 3881/4885HPGD 687/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.