Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.57 |
| ▸ | LNPEP | Q9UIQ6 | 3/20 | 0.48 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.48 |
| ▸ | YARS1 | P54577 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11880637 | 0.84 | BACE1 (0.68) | BACE1LNPEPERAP2YARS1GAA | |
| SCHEMBL16993871 | 0.84 | BACE1 (0.68) | BACE1LNPEPERAP2YARS1GAA | |
| SCHEMBL6442235 | 0.83 | CTSL (0.56) | GAAMAPTCRHBPCRHR2SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5188432 | 0.82 | BACE1 (0.67) | BACE1LNPEPERAP2YARS1HDAC8 | |
| SCHEMBL6286737 | 0.77 | BACE1 (0.63) | BACE1MAPTHDAC8HDAC3HDAC4 | |
| SCHEMBL2544232 | 0.76 | LMNA (0.77) | GAAMAPTCES2LMNACES1 | |
| SCHEMBL2903186 | 0.75 | BACE1 (0.58) | BACE1LNPEPERAP2GAAMAPT | |
| SCHEMBL7572986 | 0.75 | BACE1 (0.53) | BACE1LNPEPERAP2 | |
| SCHEMBL2312372 | 0.75 | BACE1 (0.63) | BACE1HDAC8CITSLC7A5LTA4H | |
| SCHEMBL28279157 | 0.75 | BACE1 (0.63) | BACE1HDAC8CITSLC7A5LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224322-A2 | GENE SEQUENCE VARIATIONS WITH UTILITY IN DETERMINING THE TREATMENT OF DISEASE | Variagenics, Inc. (US) | 2002-07-24 | — | — | EP | disclosed |
| WO-2000050639-A2 | GENE SEQUENCE VARIATIONS WITH UTILITY IN DETERMINING THE TREATMENT OF DISEASE | VARIAGENICS, INC. (US) | 2000-08-31 | — | — | WO | disclosed |