Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA4 | P43681 | 5/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.49 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.42 |
| ▸ | DRD1 | P21728 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | HRH1 | P35367 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29657047 | 1.00 | CHRNA4 (0.49) | CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL7583945 | 1.00 | CHRNA4 (0.49) | CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL7583938 | 1.00 | CHRNA4 (0.49) | CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL14591104 | 0.66 | CHRNB2 (1.00) | CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL10916062 | 0.63 | CHRNB2 (0.58) | CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL3206683 | 0.63 | CHRNB2 (0.58) | CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL3217847 | 0.63 | CHRNB2 (0.58) | CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL9077377 | 0.62 | MAOA (0.52) | CHRM3ADRA2AADRA2BSLC6A2SLC6A4 | |
| SCHEMBL272974 | 0.62 | MAOA (0.52) | CHRM3ADRA2AADRA2BSLC6A2SLC6A4 | |
| SCHEMBL627990 | 0.62 | MAOA (0.52) | MAOABCHELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1074552-B1 | Process for the preparation of a highly pure phenothiazine compound | SUMIKA FINE CHEMICALS CO LTD (JP) | 2002-10-09 | — | — | EP | claimed |
| US-6433168-B1 | CHEMICAL INTERMEDIATE FOR MEQUITAZINE; ANTIHISTAMINES | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2002-08-13 | — | — | US | claimed |
| EP-1074552-A2 | Process for the preparation of a highly pure phenothiazine compound | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 2001-02-07 | — | — | EP | claimed |
| CN-110204540-B | Industrial production method of mequitazine | 宁波斯迈克制药有限公司 | 2022-06-24 | — | — | CN | disclosed |
| EP-1074552-B1 | Process for the preparation of a highly pure phenothiazine compound | SUMIKA FINE CHEMICALS CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6433168-B1 | CHEMICAL INTERMEDIATE FOR MEQUITAZINE; ANTIHISTAMINES | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2002-08-13 | — | — | US | disclosed |
| EP-1074552-A2 | Process for the preparation of a highly pure phenothiazine compound | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 2001-02-07 | — | — | EP | disclosed |