SCHEMBL758498

SCHEMBL758498

Cn1[nH]c(C(F)(F)F)cc1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAD51 Q06609 7/20 0.46
ALDH1A1 P00352 5/20 0.43
KDM4E B2RXH2 3/20 0.43
BCAT2 O15382 1/20 0.38
BCAT1 P54687 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
MAOA P21397 4/20 0.35
MAOB P27338 4/20 0.35
MAPT P10636 3/20 0.34
POLB P06746 2/20 0.34
L3MBTL1 Q9Y468 2/20 0.34
LMNA P02545 1/20 0.34
BLM P54132 1/20 0.34
ATM Q13315 1/20 0.34
MEN1 O00255 2/20 0.34
GAA P10253 2/20 0.34
KMT2A Q03164 2/20 0.34
THRB P10828 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21092943 0.77 IKBKB (0.38) RAD51ALDH1A1KDM4EMAPTPOLB
SCHEMBL756979 0.72 MEN1 (0.51) RAD51ALDH1A1KDM4ECYP2C9CYP2C19
SCHEMBL486072 0.67 LMNA (0.70) ALDH1A1CYP2C9CYP2C19MAOAMAOB
SCHEMBL20014461 0.67
SCHEMBL11484476 0.64 ALDH1A1 (0.48) ALDH1A1CYP2C9MAOAMAOBMAPT
SCHEMBL24961532 0.64 KDM4E (0.50) RAD51ALDH1A1KDM4EBCAT2BCAT1
SCHEMBL8404495 0.64 KDM4E (0.40) ALDH1A1KDM4EMAPTPOLBL3MBTL1
SCHEMBL28052100 0.64 DAO (0.45) RAD51L3MBTL1MEN1KMT2A
SCHEMBL3529810 0.64 MAPT (0.44) RAD51ALDH1A1KDM4ECYP2C9CYP2C19
SCHEMBL6589202 0.63 ALDH1A1 (0.46) ALDH1A1KDM4EBCAT2BCAT1CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103951663-B Containing replacing the pyrazole amide of 1,3,4-thiadiazoles thioether and pyrazole imine analog derivative and preparation method and application 贵州大学 2016-08-17 CN claimed
CN-103951663-A Pyrazole amide and pyrazole imine derivatives containing substituted 1, 3, 4-thiadiazole thioether as well as preparation method and application of derivatives UNIV GUIZHOU 2014-07-30 CN claimed
CN-103304480-A Benzoyl parazole compound as well as synthesis method thereof and application of same as herbicide HEILONGJIANG SHENGNONG SCIENCE AND TECHNOLOGY DEV CO LTD 2013-09-18 CN claimed
EP-4563572-A1 PYRAZOLONE COMPOUND AND PYRAZOLONE AGENT The Noguchi Institute (JP) 2025-06-04 EP disclosed
US-20250129030-A1 PYRAZOLONE COMPOUND AND PYRAZOLONE AGENT THE NOGUCHI INSTITUTE (JP) 2025-04-24 US disclosed
CN-118026937-A Synthesis method of intermediate of haloxyfop-methyl for pesticides 湖北泰盛化工有限公司 2024-05-14 CN disclosed
WO-2024024760-A1 PYRAZOLONE COMPOUND AND PYRAZOLONE AGENT 公益財団法人野口研究所 2024-02-01 WO disclosed
CN-116056576-A Use of strobilurin type compounds for combating phytopathogenic fungi containing F129L amino acid substitutions conferring tolerance to Qo inhibitor VIII in mitochondrial cytochrome b proteins 巴斯夫欧洲公司 2023-05-02 CN disclosed
CN-115715189-A KCNT1 inhibitors and methods of use 普拉西斯精密医药公司 2023-02-24 CN disclosed
CN-114605326-A Sulfoxaden intermediate for pesticide and preparation method thereof 山东平宇化工有限公司 2022-06-10 CN disclosed
CN-111655687-A Novel fungicidal heterocyclic compounds PI工业有限公司 2020-09-11 CN disclosed
EP-0902026-B1 Herbicidal 2-azinyl-6-aryloxypyr(mi)dines BASF AG (DE) 2006-04-12 EP disclosed
US-20030216394-A1 Etylene derivatives and pesticides containing said derivatives NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2003-11-20 US disclosed
EP-1360901-A1 2,3-cyclic substituted derivatives of 3-hydroxyacrolein and 3-hydroxyacrylic acid as pesticides NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) 2003-11-12 EP disclosed
US-RE38188-E1 Ethylene derivatives and pesticides containing said derivatives NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2003-07-15 US disclosed
EP-0913392-B1 ETHYLENE DERIVATIVES AND PEST CONTROLLING AGENTS NISSAN CHEMICAL IND LTD (JP) 2003-07-02 EP disclosed
US-6462049-B1 LOW TOXICITY AND PERSISTENT INSECTICIDES AND FUNGICIDES; PREVENTING ATTACHMENT OF AQUATIC ORGANISMS; ECOSYSTEM FRIENDLY; NONPOLLUTING NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2002-10-08 US disclosed
US-6063734-A AGRICULTURAL CHEMICALS, AGENTS FOR PREVENTING ATTACHMENT OF AQUATIC ORGANISMS NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2000-05-16 US disclosed
EP-0913392-A1 ETHYLENE DERIVATIVES AND PEST CONTROLLING AGENTS NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) 1999-05-06 EP disclosed
EP-0902026-A1 Herbicidal 2-azinyl-6-aryloxypyr (mi) dines American Cyanamid Company (US) 1999-03-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030216394-A1 Etylene derivatives and pesticides containing said derivatives DDT, ECE1, EBPL RAD51 2650/4885ALDH1A1 357/4885KDM4E 330/4885
US-20250129030-A1 PYRAZOLONE COMPOUND AND PYRAZOLONE AGENT NPM1, PLK3, PKN2 RAD51 1675/4885ALDH1A1 1437/4885KDM4E 3809/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.