Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.62 |
| ▸ | TNKS | O95271 | 1/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | IDE | P14735 | 1/20 | 0.44 |
| ▸ | MPI | P34949 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.44 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.44 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | NGFR | P08138 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 4/20 | 0.42 |
| ▸ | DDO | Q99489 | 3/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7250753 | 0.82 | KDM4E (0.52) | PARP1TNKSTNKS2CA12CA9 | |
| SCHEMBL7250779 | 0.77 | PARP1 (0.66) | PARP1TNKSTNKS2CA12CA9 | |
| SCHEMBL1230435 | 0.77 | PARP1 (1.00) | PARP1TNKSTNKS2KDM4EALDH1A1 | |
| SCHEMBL20597354 | 0.70 | IMPDH2 (0.67) | PARP1TNKSTNKS2CA12CA9 | |
| SCHEMBL1771631 | 0.70 | KDM4E (0.59) | PARP1CA12CA9KDM4EALDH1A1 | |
| SCHEMBL7252401 | 0.70 | ROCK2 (0.52) | PARP1KDM4EALDH1A1MAPTCDK2 | |
| SCHEMBL4610600 | 0.70 | PARP1 (0.62) | PARP1CA12CA9KDM4EALDH1A1 | |
| SCHEMBL1549859 | 0.69 | TNKS2 (0.60) | PARP1TNKSTNKS2KDM4EALDH1A1 | |
| SCHEMBL14449851 | 0.69 | KDM4E (0.70) | PARP1KDM4EMAPTCDK2 | |
| SCHEMBL5879153 | 0.68 | CHEK1 (0.59) | PARP1CA12CA9NGFRAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6348475-B1 | POLYMERASE INHIBITOR | GUILFORD PHARMACEUTICALS INC. | 2002-02-19 | — | — | US | disclosed |
| US-20020019417-A1 | Methods, compounds and compositions for treating gout | EISAI INC. | 2002-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020019417-A1 | Methods, compounds and compositions for treating gout | PARP2, PARP1, PARP3 | PARP1 2/4885TNKS 22/4885TNKS2 39/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.