Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 13/20 | 0.50 |
| ▸ | CTSL | P07711 | 8/20 | 0.46 |
| ▸ | CTSB | P07858 | 8/20 | 0.46 |
| ▸ | CTSH | P09668 | 5/20 | 0.46 |
| ▸ | CTSS | P25774 | 3/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5528178 | 0.87 | CTSK (0.48) | CTSKCTSLCTSBCTSHCTSS | |
| SCHEMBL5527109 | 0.87 | CTSK (0.48) | CTSKCTSLCTSBCTSHCTSS | |
| SCHEMBL5523001 | 0.83 | CTSK (0.51) | CTSKCTSLCTSBCTSHCTSS | |
| SCHEMBL5526860 | 0.82 | CTSK (0.50) | CTSKCTSLCTSBCTSHCTSS | |
| SCHEMBL5529190 | 0.80 | CTSL (0.48) | CTSKCTSLCTSBCTSHCTSS | |
| SCHEMBL5528340 | 0.80 | CTSL (0.48) | CTSKCTSLCTSBCTSHCTSS | |
| SCHEMBL5527441 | 0.80 | CTSK (0.61) | CTSKCTSLCTSBCTSHCTSS | |
| SCHEMBL5523059 | 0.77 | CTSS (0.53) | CTSKCTSLCTSBCTSHCTSS | |
| SCHEMBL5525335 | 0.74 | CTSL (0.69) | CTSKCTSLCTSBCTSSCHRNB2 | |
| SCHEMBL5530441 | 0.74 | CTSL (0.69) | CTSKCTSLCTSBCTSSCHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178958-A2 | N-CYANOMETHYL AMIDES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000055125-A2 | N-CYANOMETHYL AMIDES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |