Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7582205 | 0.92 | DRD2 (0.38) | DRD2SIGMAR1DRD3HTR1AKDM4E | |
| SCHEMBL7585162 | 0.91 | CHRNA7 (0.42) | HTR1AKDM4ELMNAGAA | |
| SCHEMBL7585760 | 0.90 | TACR1 (0.39) | DRD2DRD3HTR1ALMNAHTR2A | |
| SCHEMBL7584119 | 0.90 | TACR1 (0.39) | DRD2DRD3HTR1ALMNAHTR2A | |
| SCHEMBL7591499 | 0.90 | TACR1 (0.39) | DRD2DRD3HTR1ALMNAHTR2A | |
| SCHEMBL7584388 | 0.86 | TP53 (0.43) | DRD2DRD3HTR1ALMNAADRA1A | |
| SCHEMBL7585930 | 0.85 | CHRNA7 (0.40) | DRD2SIGMAR1DRD3HTR1AKDM4E | |
| SCHEMBL7585779 | 0.85 | SIGMAR1 (0.41) | DRD2SIGMAR1DRD3HTR1AHTR2A | |
| SCHEMBL7583647 | 0.84 | TACR1 (0.38) | DRD2DRD3HTR1ALMNAHTR2A | |
| SCHEMBL7582692 | 0.82 | CHRNA7 (0.47) | DRD2SIGMAR1HTR1AKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | claimed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | claimed |
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |