Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 15/20 | 0.58 |
| ▸ | HTR2A | P28223 | 12/20 | 0.58 |
| ▸ | HTR2C | P28335 | 12/20 | 0.58 |
| ▸ | HTR2B | P41595 | 12/20 | 0.58 |
| ▸ | DRD2 | P14416 | 12/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6836323 | 0.94 | SIGMAR1 (0.64) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL6836322 | 0.94 | SIGMAR1 (0.64) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL7587346 | 0.86 | SIGMAR1 (0.73) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL6843243 | 0.82 | SIGMAR1 (0.55) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL6841101 | 0.82 | DRD2 (0.55) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL6840814 | 0.82 | SIGMAR1 (0.66) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL6836327 | 0.78 | KDM4E (0.45) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL6840845 | 0.78 | SIGMAR1 (0.66) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL14045655 | 0.75 | ALDH1A1 (0.63) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL6841555 | 0.75 | ALDH1A1 (0.47) | SIGMAR1HTR2AHTR2BDRD2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235808-A2 | TRICYCLIC ANALGESICS | WARNER-LAMBERT COMPANY (US) | 2002-09-04 | — | — | EP | claimed |
| WO-2000075116-A2 | TRICYCLIC ANALGESICS | WARNER-LAMBERT COMPANY (US) | 2000-12-14 | — | — | WO | claimed |