Acifluorfen

Acifluorfen

SCHEMBL7586534

CCNc1nc(Cl)nc(NC(C)(C)C)n1.CP(=O)(O)CCC(N)C(=O)O.O=C(O)c1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-]

nearest known ligand 0.53

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.53
MEN1 O00255 2/20 0.53
KMT2A Q03164 2/20 0.53
TTR P02766 1/20 0.53
PPOX P50336 1/20 0.53
PYGL P06737 1/20 0.35
FFAR1 O14842 2/20 0.35
GRM4 Q14833 9/20 0.35
GRM8 O00222 8/20 0.35
GRM6 O15303 6/20 0.35
LMNA P02545 3/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
POLB P06746 2/20 0.32
ALDH1A1 P00352 1/20 0.32
MAPT P10636 1/20 0.32
CCR6 P51684 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
GPR55 Q9Y2T6 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acifluorfen SCHEMBL7581016 0.96 TDP1 (0.57) TDP1MEN1KMT2ATTRPPOX
Acifluorfen SCHEMBL7581029 0.94 KMT2A (0.51) TDP1MEN1KMT2ATTRPPOX
Acifluorfen SCHEMBL7584131 0.94 TDP1 (0.50) TDP1MEN1KMT2ATTRPPOX
Fomesafen SCHEMBL7576308 0.93 TDP1 (0.45) TDP1MEN1KMT2ATTRPPOX
Acifluorfen SCHEMBL7580896 0.93 TDP1 (0.53) TDP1MEN1KMT2ATTRPPOX
Oxyfluorfen SCHEMBL7581319 0.92 MEN1 (0.42) TDP1MEN1KMT2ATTRPPOX
Terbuthylazine SCHEMBL7576407 0.92 TDP1 (0.43) TDP1MEN1KMT2ATTRPPOX
Acifluorfen SCHEMBL7578460 0.89 KMT2A (0.67) TDP1MEN1KMT2ATTRPPOX
Fomesafen SCHEMBL7588428 0.89 TDP1 (0.48) TDP1MEN1KMT2ATTRPPOX
Oxyfluorfen SCHEMBL7589088 0.88 MEN1 (0.45) TDP1MEN1KMT2ATTRPPOX

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020004457-A1 Herbicidal composition SYNGENTA PARTICIPATIONS AG (CH) 2002-01-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020004457-A1 Herbicidal composition PPOX, ALAD, DDT TDP1 1969/4885MEN1 4274/4885KMT2A 2099/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.