Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | DRD2 | P14416 | 6/20 | 0.33 |
| ▸ | DRD4 | P21917 | 4/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7582141 | 0.97 | KDM4E (0.38) | KDM4EGAAKCNH2DRD2DRD4 | |
| SCHEMBL7581935 | 0.96 | KDM4E (0.40) | KDM4EGAAKCNH2DRD2DRD4 | |
| SCHEMBL7581291 | 0.96 | KDM4E (0.40) | KDM4EGAAKCNH2DRD2DRD4 | |
| SCHEMBL7582764 | 0.93 | DRD2 (0.38) | KDM4EGAADRD2DRD3ALDH1A1 | |
| SCHEMBL7582136 | 0.88 | DRD2 (0.33) | DRD2DRD3 | |
| SCHEMBL7581302 | 0.81 | SLC6A2 (0.33) | KDM4EGAA | |
| SCHEMBL7586137 | 0.80 | DRD2 (0.39) | KDM4EGAADRD2DRD3ALDH1A1 | |
| SCHEMBL7591694 | 0.80 | DRD2 (0.39) | DRD2DRD4DRD3ALDH1A1HTR1A | |
| SCHEMBL7584423 | 0.80 | DRD2 (0.39) | KDM4EGAADRD2DRD3ALDH1A1 | |
| SCHEMBL7955773 | 0.80 | SLC6A2 (0.34) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |