Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 7/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7591886 | 0.82 | NPC1 (0.50) | NPC1AKR1B1KDM4ENPSR1SMN1; SMN2 | |
| SCHEMBL27480347 | 0.81 | ALDH1A1 (0.41) | NPSR1SMN1; SMN2GPR35MAPTLMNA | |
| SCHEMBL7582706 | 0.75 | ALDH1A1 (0.41) | KDM4ENPSR1MAPTMAPK1TDP1 | |
| SCHEMBL7587383 | 0.72 | ALDH1A1 (0.46) | NPSR1SMN1; SMN2GPR35MAPTMAPK1 | |
| SCHEMBL7589858 | 0.72 | ALDH1A1 (0.48) | SMN1; SMN2MAPTMAPK1TDP1LMNA | |
| SCHEMBL6587015 | 0.71 | KDM4E (0.54) | FBP1THRBKDM4ENPSR1SMN1; SMN2 | |
| SCHEMBL7587421 | 0.70 | NPC1 (0.51) | NPC1AKR1B1NPSR1SMN1; SMN2MAPT | |
| SCHEMBL1684398 | 0.70 | ALDH1A1 (0.44) | FBP1KDM4ESMN1; SMN2MAPTMAPK1 | |
| SCHEMBL20298736 | 0.69 | NPC1 (0.50) | NPC1AKR1B1KDM4ENPSR1SMN1; SMN2 | |
| SCHEMBL28057357 | 0.69 | NPC1 (0.50) | NPC1SMN1; SMN2MAPTMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| US-5849912-A | Biphenyl derivatives | EISAI CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |