Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | ESPL1 | Q14674 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7591886 | 0.81 | NPC1 (0.50) | ALDH1A1LMNANPSR1KDM4EPOLB | |
| SCHEMBL7587383 | 0.81 | ALDH1A1 (0.46) | ALDH1A1ESPL1CYP3A4LMNANPSR1 | |
| SCHEMBL7589858 | 0.81 | ALDH1A1 (0.48) | ALDH1A1ESPL1CYP3A4LMNAHTT | |
| SCHEMBL27480347 | 0.79 | ALDH1A1 (0.41) | ALDH1A1ESPL1CYP3A4LMNANPSR1 | |
| SCHEMBL27724891 | 0.78 | TP53 (0.46) | ALDH1A1CYP3A4HTTTP53POLB | |
| SCHEMBL7586768 | 0.75 | FBP1 (0.39) | LMNANPSR1KDM4EPOLBKMT2A | |
| SCHEMBL6568119 | 0.75 | KDM4E (0.58) | CYP3A4LMNANPSR1KDM4ETP53 | |
| SCHEMBL27581325 | 0.73 | PTGER4 (0.38) | ALDH1A1LMNANPSR1HTTPOLB | |
| SCHEMBL8875661 | 0.72 | AKR1B1 (0.53) | ALDH1A1CYP3A4LMNAHTTTP53 | |
| SCHEMBL13338136 | 0.72 | KMT2A (0.51) | ALDH1A1LMNANPSR1KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1114596-C | Biphenyl derivatives | EISAI CO LTD (JP) | 2003-07-16 | — | — | CN | disclosed |
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| CN-1290700-A | Phenyl piperazine derivatives | EISAI LTD (JP) | 2001-04-11 | — | — | CN | disclosed |
| US-5849912-A | Biphenyl derivatives | EISAI CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |
| CN-1117966-A | Biphenyl derivatives | EISAI CO LTD (JP) | 1996-03-06 | — | — | CN | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |