Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CTSV | O60911 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13531820 | 0.87 | ALDH1A1 (0.54) | ALDH1A1CYP1A2CYP2D6CYP2C19MAPT | |
| SCHEMBL7587383 | 0.86 | ALDH1A1 (0.46) | ALDH1A1CYP1A2CYP2D6CYP2C19MAPT | |
| SCHEMBL2034609 | 0.82 | ALDH1A1 (0.64) | ALDH1A1CYP1A2CYP2D6CYP2C19MAPT | |
| SCHEMBL27480347 | 0.81 | ALDH1A1 (0.41) | ALDH1A1MAPTCYP3A4LMNAHTT | |
| SCHEMBL7582706 | 0.81 | ALDH1A1 (0.41) | ALDH1A1MAPTCYP3A4TDP1MAPK1 | |
| SCHEMBL1487913 | 0.81 | CA1 (0.53) | ALDH1A1CYP1A2CYP2D6CYP2C19MAPT | |
| SCHEMBL19357885 | 0.81 | CA1 (0.49) | ALDH1A1CYP1A2MAPTCYP3A4ALOX15 | |
| SCHEMBL8841205 | 0.80 | ALDH1A1 (0.50) | ALDH1A1MAPTCYP3A4ALOX15TDP1 | |
| SCHEMBL25287029 | 0.79 | ALDH1A1 (0.44) | ALDH1A1MAPTCYP3A4ALOX15TDP1 | |
| SCHEMBL22032848 | 0.79 | ALDH1A1 (0.46) | ALDH1A1CYP1A2CYP2D6CYP2C19MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102427726-B | fused ring inhibitors of hepatitis c | PRESIDIO PHARMACEUTICALS, INC. (US) | 2014-10-08 | — | — | CN | disclosed |
| CN-103596951-A | 8-ethyl-6-(aryl)pyrido [2,3-d]pyrimidin-7(8h)-ones for the treatment of nervous system disorders and cancer | AFRAXIS INC | 2014-02-19 | — | — | CN | disclosed |
| CN-1114596-C | Biphenyl derivatives | EISAI CO LTD (JP) | 2003-07-16 | — | — | CN | disclosed |
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| CN-1290700-A | Phenyl piperazine derivatives | EISAI LTD (JP) | 2001-04-11 | — | — | CN | disclosed |
| US-5849912-A | Biphenyl derivatives | EISAI CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |
| CN-1117966-A | Biphenyl derivatives | EISAI CO LTD (JP) | 1996-03-06 | — | — | CN | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |