Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 6/20 | 0.61 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.53 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.53 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.51 |
| ▸ | HTR3B | O95264 | 1/20 | 0.51 |
| ▸ | HTR3A | P46098 | 1/20 | 0.51 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.51 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.45 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7507944 | 0.80 | ADRB1 (0.62) | ADRB1CHRNB2CHRNA4HTR3EHTR3B | |
| SCHEMBL335755 | 0.80 | ADRB1 (0.62) | ADRB1CHRNB2CHRNA4HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL8931722 | 0.79 | ADRB1 (0.61) | ADRB1CHRNB2CHRNA4HTR3EHTR3B | |
| SCHEMBL4939296 | 0.79 | ADRB1 (0.61) | ADRB1CHRNB2CHRNA4HTR3EHTR3B | |
| Bromide SCHEMBL10572729 | 0.79 | ADRB1 (0.61) | ADRB1CHRNB2CHRNA4HTR3EHTR3B | |
| SCHEMBL5245685 | 0.79 | ADRB1 (0.61) | ADRB1CHRNB2CHRNA4HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL4934648 | 0.77 | ADRB1 (0.59) | ADRB1CHRNB2CHRNA4HTR3EHTR3B | |
| SCHEMBL7587341 | 0.76 | ADRB1 (0.62) | ADRB1CHRNB2CHRNA4HTR3EHTR3B | |
| SCHEMBL443521 | 0.76 | ADRB1 (1.00) | ADRB1CHRNB2CHRNA4HTR3EHTR3B | |
| SCHEMBL255446 | 0.75 | CHRNB2 (0.60) | ADRB1CHRNB2CHRNA4HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| US-5849912-A | Biphenyl derivatives | EISAI CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |